ArticlePloS one2009
Boule is present in fish and bisexually expressed in adult and embryonic germ cells of medaka.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- The Seasonal and Stage-Specific Expression Patterns of HMGB2 Suggest Its Key Role in Spermatogenesis in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis).Biochemical genetics · 2022Article
- Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals.Stem cells international · 2022Review
- Expressional Profiling ofBiology · 2021Article
- Isolation and Characterization of Highly Pure Type A Spermatogonia From Sterlet (Frontiers in cell and developmental biology · 2021Article
- Primordial Germ Cell Specification in Vertebrate Embryos: Phylogenetic Distribution and Conserved Molecular Features of Preformation and Induction.Frontiers in cell and developmental biology · 2021Review
- Histomorphological Comparisons and Expression Patterns ofAnimals : an open access journal from MDPI · 2019Article
- MiR-202-5p is a novel germ plasm-specific microRNA in zebrafish.Scientific reports · 2017Article
- Black carp vasa identifies embryonic and gonadal germ cells.Development genes and evolution · 2017Article
- The Conservation of the Germline Multipotency Program, from Sponges to Vertebrates: A Stepping Stone to Understanding the Somatic and Germline Origins.Genome biology and evolution · 2017Article
- Germline replacement by blastula cell transplantation in the fish medaka.Scientific reports · 2016Article
- Identification of gonadal soma-derived factor involvement in Monopterus albus (protogynous rice field eel) sex change.Molecular biology reports · 2016Article
- Dazl is a critical player for primordial germ cell formation in medaka.Scientific reports · 2016Article
- Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish.Stem cell reports · 2016Article
- Autosomal gsdf acts as a male sex initiator in the fish medaka.Scientific reports · 2016Article
- Medaka Oct4 is essential for pluripotency in blastula formation and ES cell derivation.Stem cell reviews and reports · 2015Article
- Prevalent RNA recognition motif duplication in the human genome.RNA (New York, N.Y.) · 2014Article
- Vasa identifies germ cells and critical stages of oogenesis in the Asian seabass.International journal of biological sciences · 2014Article
- Splice variants and promoter methylation status of the Bovine Vasa Homology (Bvh) gene may be involved in bull spermatogenesis.BMC genetics · 2013Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe DAZ family genes boule, daz and dazl encode RNA binding proteins essential for fertility of diverse animals including human. dazl has bisexual expression in both mitotic and meiotic germ cells, whereas daz has male premeiotic expression, and boule is largely a unisexual meiotic regulator. Although boule has been proposed as the ancestor for dazl/daz by gene duplication, it has been identified only in invertebrates and mammals. It has, however, remained unclear when and how the DAZ family has evolved in vertebrates. METHODOLOGY AND PRINCIPAL
findingsThis study was aimed at identifying and characterizing the DAZ family genes in fish as the basal vertebrate. We show that boule and dazl coexist in medaka and stickleback. Similar to the medaka dazl (Odazl), the medaka boule (Obol) is maternally supplied and segregates with primordial germ cells. Surprisingly, Obol is expressed in adult germ cells at pre-meiotic and meiotic stages of spermatogenesis and oogenesis. However, the maximal meiotic Obol expression in spermatocytes contrasts with the predominant pre-meiotic Odazl expression in spermatogonia, and the diffuse cytoplasmic Obol distribution in early oocytes contrasts with the Odazl concentration in the Balbinani's body.
conclusionsThe identification of fish boule and dazl genes provides direct evidence for the early gene duplication during vertebrate evolution. Our finding that Obol exhibits bisexual expression in both embryonic and adult germ cells considerably extends the diversity of boule expression patterns and offers a new insight into the evolutions of DAZ family members, expression patterns and functions in animal fertility.
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