ReviewNature reviews. Endocrinology2009
Genomics of type 2 diabetes mellitus: implications for the clinician.
Review in Nature reviews. Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00018889 (Phenotype/Genotype Correlations in Movement Disorders), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phenotype/Genotype Correlations in Movement Disorders
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Pooled it
- Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism.Diabetologia · 2012Pooled it
- The effect of genetic counseling for adult offspring of patients with type 2 diabetes on attitudes toward diabetes and its heredity: a randomized controlled trial.Journal of genetic counseling · 2014Trial
- Dual peroxisome proliferator-activated receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects.Diabetes care · 2013Trial
- Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial.BMC public health · 2012Trial
- Trial
- Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: a pilot study.Diabetes care · 2010 · on this mapTrial
- Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance.Diabetologia · 2023Article
- A Bittersweet Response to Infection in Diabetes; Targeting Neutrophils to Modify Inflammation and Improve Host Immunity.Frontiers in immunology · 2021Review
- Development and validation of a predictive model for incident type 2 diabetes in middle-aged Mexican adults: the metabolic syndrome cohort.BMC endocrine disorders · 2019Observational
- Relation of the rs6923761 gene variant in glucagon-like peptide 1 receptor with weight, cardiovascular risk factor, and serum adipokine levels in obese female subjects.Journal of clinical laboratory analysis · 2015Article
- Role of rs6923761 gene variant in glucagon-like peptide 1 receptor in basal GLP-1 levels, cardiovascular risk factor and serum adipokine levels in naïve type 2 diabetic patients.Journal of endocrinological investigation · 2015Article
- The Human Genome Project, and recent advances in personalized genomics.Risk management and healthcare policy · 2015Review
- Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance.Frontiers in endocrinology · 2014Article
- The 2010 ESPEN Sir David Cuthbertson Lecture: new and old proteins: clinical implications.Clinical nutrition (Edinburgh, Scotland) · 2013Article
- Gene variants associated with antisocial behaviour: a latent variable approach.Journal of child psychology and psychiatry, and allied disciplines · 2013Article
- Osteocalcin and the Regulation of Glucose Metabolism.Clinical reviews in bone and mineral metabolism · 2013Article
- Insulin signaling and insulin resistance.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2013Review
- IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2012Article
- Randomized controlled trial of the effectiveness of genetic counseling and a distance, computer-based, lifestyle intervention program for adult offspring of patients with type 2 diabetes: background, study protocol, and baseline patient characteristics.Journal of nutrition and metabolism · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Our understanding of the genetics of type 2 diabetes mellitus (T2DM) has changed, in part owing to implementation of genome-wide association studies as a method for unraveling the genetic architecture of complex traits. These studies enable a global search throughout the nuclear genome for variants that are associated with specific phenotypes. Currently, single nucleotide polymorphisms in about 24 different genetic loci have been associated with T2DM. Most of these genetic loci are associated with the insulin secretion pathway rather than insulin resistance. Study design, heritability differences and the intrinsic properties of in vivo insulin resistance measures might partially explain why only a few loci associated with insulin resistance have been detected through genome-wide association approaches. Despite the success of these approaches at detecting loci associated with T2DM, currently known associations explain only a small amount of the genetic variance involved in the disease. Compared with previous studies, larger cohorts might be needed to identify variants of smaller effect sizes and lower allele frequencies. Finally, the current list of genetic loci that are related to T2DM does not seem to offer greater predictive value in determining diabetes risk than do commonly used phenotypic risk factors and family history.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.