ArticleProceedings of the National Academy of Sciences of the United States of America2009
Control of retinal isomerization in bacteriorhodopsin in the high-intensity regime.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Optical coherent quantum control of ultrafast protein electron transfer.Science advances · 2025Article
- Resonant multiphoton processes and excitation limits to structural dynamics.Structural dynamics (Melville, N.Y.) · 2024Article
- Serial Femtosecond Crystallography Reveals that Photoactivation in a Fluorescent Protein Proceeds via the Hula Twist Mechanism.Journal of the American Chemical Society · 2023Article
- Voltage Imaging with Engineered Proton-Pumping Rhodopsins: Insights from the Proton Transfer Pathway.ACS physical chemistry Au · 2023Review
- Ultrafast pulse shaping modulates perceived visual brightness in living animals.Science advances · 2021Article
- Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin.Nature communications · 2019Article
- Coherent-control of linear signals: frequency-domain analysis.The Journal of chemical physics · 2013Article
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Authors and funding
6 authors.
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Abstract
A learning algorithm was used to manipulate optical pulse shapes and optimize retinal isomerization in bacteriorhodopsin, for excitation levels up to 1.8 x 10(16) photons per square centimeter. Below 1/3 the maximum excitation level, the yield was not sensitive to pulse shape. Above this level the learning algorithm found that a Fourier-transform-limited (TL) pulse maximized the 13-cis population. For this optimal pulse the yield increases linearly with intensity well beyond the saturation of the first excited state. To understand these results we performed systematic searches varying the chirp and energy of the pump pulses while monitoring the isomerization yield. The results are interpreted including the influence of 1-photon and multiphoton transitions. The population dynamics in each intermediate conformation and the final branching ratio between the all-trans and 13-cis isomers are modified by changes in the pulse energy and duration.
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