ArticleNeurology2009
Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis.
Article in Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01337986 (Dalfampridine After Optic Neuritis to Improve Visual Function in Multiple Sclerosis), which is not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dalfampridine After Optic Neuritis to Improve Visual Function in Multiple Sclerosis
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuro-ophthalmic complications of tuberculosis and its treatment: a systematic review and meta-analysis.Frontiers in ophthalmology · 2026Pooled it
- Effect of Treating Acute Optic Neuritis With Bioequivalent Oral vs Intravenous Corticosteroids: A Randomized Clinical Trial.JAMA neurology · 2018Trial
- Amiloride Clinical Trial In Optic Neuritis (ACTION) protocol: a randomised, double blind, placebo controlled trial.BMJ open · 2015Trial
- Memantine for axonal loss of optic neuritis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2012Trial
- Retinal nerve fibre layer thinning in patients with clinically isolated optic neuritis and early treatment with interferon-beta.PloS one · 2012Trial
- The supporting role of Visual Evoked Potentials for the diagnosis of Optic Neuritis within the 2022 ICON criteria.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Imaging biomarkers in optic neuritis: current tools and future directions.Frontiers in neurology · 2025Review
- Evaluation of transorbital sonography measures of optic nerve diameter in the context of global and regional brain volume in multiple sclerosis.Scientific reports · 2023Article
- Modulation of cortical activity by spherical blur and its correlation with retinal defocus.Frontiers in neuroscience · 2023Article
- Different visual evoked potentials in neuromyelitis optica spectrum disorder-related optic neuritis and idiopathic demyelinating optic neuritis: a prospective longitudinal analysis.BMC ophthalmology · 2022Article
- Neuroprotective Effects of Novel Treatments on Acute Optic Neuritis-A Meta-Analysis.Biomedicines · 2022Article
- Low Contrast Visual Evoked Potentials for Early Detection of Optic Neuritis.Frontiers in neurology · 2022Article
- The effect of optic neuritis treatment trial (ONTT) combined corticosteroid regimen on pattern reversal visual evoked potentials: a prospective follow-up study.BMC ophthalmology · 2021Observational
- Using advanced analysis of multifocal visual-evoked potentials to evaluate the risk of clinical progression in patients with radiologically isolated syndrome.Scientific reports · 2021Article
- The value of the visual evoked potentials test in the assessment of the visual pathway in head trauma.Journal of injury & violence research · 2021Article
- Atypical optic neuritis: An overview.Indian journal of ophthalmology · 2021Review
- Electro-oculography in bilateral optic neuropathy.BMC research notes · 2020Observational
- The Role of Optical Coherence Tomography in Differential Diagnosis of Multiple Sclerosis and Autoimmune Connective Tissue Diseases with CNS Involvement.Journal of clinical medicine · 2020Article
- Functional-structural assessment of the optic pathways in patients with optic neuritis.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- In vivo structural and functional assessment of optic nerve damage in neuromyelitis optica spectrum disorders and multiple sclerosis.Scientific reports · 2019Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesDetermine the utility of optical coherence tomography (OCT) to detect clinical and subclinical remote optic neuritis (ON), its relationship to clinical characteristics of ON and visual function, and whether the retinal nerve fiber layer (RNFL) thickness functions as a surrogate marker of global disease severity.
methodsCross-sectional study of 65 subjects with at least 1 clinical ON episode at least 6 months prior. Measures included clinical characteristics, visual acuity (VA), contrast sensitivity (CS), OCT, and visual evoked potentials (VEP).
resultsNinety-six clinically affected optic nerves were studied. The sensitivity of OCT RNFL after ON was 60%, decreasing further with mild onset and good recovery. VEP sensitivity was superior at 81% (p = 0.002). Subclinical ON in the unaffected eye was present in 32%. VEP identified 75% of all subclinically affected eyes, and OCT identified <20%. RNFL thickness demonstrated linear correlations with VA (r = 0.65) and CS (r = 0.72) but was unable to distinguish visual categories <20/50. RNFL was thinner with severe onset and disease recurrence but was unaffected by IV glucocorticoids. OCT measurements were not related to overall disability, ethnicity, sex, or age at onset. The greatest predictor for RNFL in the unaffected eye was the RNFL in the fellow affected eye.
conclusionsVisual evoked potentials (VEP) remains the preferred test for detecting clinical and subclinical optic neuritis. Optical coherence tomography (OCT) measures were unrelated to disability and demographic features predicting a worse prognosis in multiple sclerosis. OCT may provide complementary information to VEP in select cases, and remains a valuable research tool for studying optic nerve disease in populations.
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