ArticleMolecular and cellular biology2009
The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
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- Divide or Commit - Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis.Frontiers in cell and developmental biology · 2019Review
- Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway inOncotarget · 2018Article
- Tissue-specific targeting of cell fate regulatory genes by E2f factors.Cell death and differentiation · 2016Article
- Role of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb.Scientific reports · 2016Article
- Transcriptional control of stem cell fate by E2Fs and pocket proteins.Frontiers in genetics · 2015Review
- Control of glutamine metabolism by the tumor suppressor Rb.Oncogene · 2014Article
- Cell cycle regulation during neurogenesis in the embryonic and adult brain.Stem cell reviews and reports · 2013Review
- Tumor suppressive pathways in the control of neurogenesis.Cellular and molecular life sciences : CMLS · 2013Review
- Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation.Alcoholism, clinical and experimental research · 2011Article
- Article
- Rb/E2F regulates expression of neogenin during neuronal migration.Molecular and cellular biology · 2011Article
- p107 in the public eye: an Rb understudy and more.Cell division · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that p107, a member of the retinoblastoma (Rb) cell cycle regulatory family, has a unique function in regulating the pool of neural precursor cells. As the pool of progenitors is regulated by a limiting supply of trophic factors, we asked if the Rb/E2F pathway may control the size of the progenitor population by regulating the levels of growth factors or their receptors. Here, we demonstrate that fibroblast growth factor 2 (FGF2) is aberrantly upregulated in the brains of animals lacking Rb family proteins and that the gene encoding the FGF2 ligand is directly regulated by p107 and E2F3. Chromatin immunoprecipitation assays demonstrated that E2F3 and p107 occupy E2F consensus sites on the FGF2 promoter in the context of native chromatin. To evaluate the physiological consequence of FGF2 deregulation in both p107 and E2F3 mutants, we measured neural progenitor responsiveness to growth factors. Our results demonstrate that E2F3 and p107 are each mediators of FGF2 growth factor responsiveness in neural progenitor cells. These results support a model whereby p107 regulates the pool of FGF-responsive progenitors by directly regulating FGF2 gene expression in vivo. By identifying novel roles for p107/E2F in regulating genes outside of the classical cell cycle machinery targets, we uncover a new mechanism whereby Rb/E2F mediates proliferation through regulating growth factor responsiveness.
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Registered trials
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