ArticleThe Journal of physiology2009
Homocysteine transport by systems L, A and y+L across the microvillous plasma membrane of human placenta.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Developmental modulation of schizophrenia risk gene methylation in offspring exhibiting cognitive deficits following maternal immune activation.Molecular psychiatry · 2026Article
- Maternal methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism: implications in preventing recurrent pregnancy loss.Journal of preventive medicine and hygiene · 2024Article
- The Protective Effects of Hydrogen Sulfide New Donor MethylMolecules (Basel, Switzerland) · 2022Article
- Homocysteine Metabolism in Pregnancy and Developmental Impacts.Frontiers in cell and developmental biology · 2022Review
- Effects of Dietary Choline Levels During Pregnancy on Reproductive Performance, Plasma Metabolome and Gut Microbiota of Sows.Frontiers in veterinary science · 2021Article
- A Novel Review of Homocysteine and Pregnancy Complications.BioMed research international · 2021Review
- Methylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome.Geburtshilfe und Frauenheilkunde · 2018Article
- Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia.BMC genomics · 2018Article
- One carbon metabolism in pregnancy: Impact on maternal, fetal and neonatal health.Molecular and cellular endocrinology · 2016Review
- Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Computational modelling of amino acid exchange and facilitated transport in placental membrane vesicles.Journal of theoretical biology · 2015Article
- L-methionine placental uptake: characterization and modulation in gestational diabetes mellitus.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results.Lipids in health and disease · 2013Article
- Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells.Cellular and molecular neurobiology · 2013Article
- Methionine, homocysteine, one carbon metabolism and fetal growth.Reviews in endocrine & metabolic disorders · 2012Review
- Homocysteine is transported by the microvillous plasma membrane of human placenta.Journal of inherited metabolic disease · 2011Review
- Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy.Experimental diabetes research · 2011Review
- Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.Nutrition research (New York, N.Y.) · 2010Article
- Novel mechanism causing restricted fetal growth: does maternal homocysteine impair placental amino acid transport?The Journal of physiology · 2009Article
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6 authors at 4 institutions in 2 countries.
Funding
Abstract
Elevated maternal plasma levels of homocysteine (Hcy) are associated with pregnancy complications and adverse neonatal outcomes, suggesting placental transport of Hcy may impact on fetal development. However, such transport mechanisms have not been defined. In this study we characterise Hcy transport mechanisms across the microvillous plasma membrane (MVM) of the syncytiotrophoblast, the transporting epithelium of human placenta. Three candidate transport systems, systems L, A and y(+)L, were examined utilising competitive inhibition to investigate the effects of Hcy on the uptake of well-characterised radiolabelled substrates for each system into isolated MVM vesicles, and that of model substrates on 10 microm [(35)S]l-Hcy uptake. System L activity was inhibited by both l-Hcy and dl-Hcy, comparable to model substrates including 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH). System L constituted the major transport mechanism, with significant BCH inhibition (69%) of [(35)S]l-Hcy uptake. System A activity was also inhibited by l-Hcy and dl-Hcy with a smaller contribution (21%) to [(35)S]l-Hcy uptake. Inhibition by l-Hcy and dl-Hcy of system y(+)L activity was Na(+) sensitive with a significant inhibition constant (K(i)) shift observed following K(+) replacement; l-arginine reduced [(35)S]l-Hcy uptake by 19%. Kinetic modelling of [(35)S]l-Hcy uptake resolved two, Na(+)-independent, transport components (K(m) 72 microm and 9.7 mm). This study provides evidence for the involvement of systems L, A and y(+)L in placental Hcy transport. Such transport, by competing with endogenous amino acids for transporter activity, could have major implications for syncytiotrophoblast metabolism and function as well as fetal development.
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