ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 112 citations in OpenAlex.
- Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes.The Journal of clinical investigation · 2020Trial
- T-Cell Subsets Predict Mortality in Malnourished Zambian Adults Initiating Antiretroviral Therapy.PloS one · 2015Trial
- T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.PLoS pathogens · 2014Trial
- Trial
- High Frequencies of Senescent and Exhausted Natural Killer Cells and SARS-CoV-2-Specific Memory CD8Viruses · 2026Article
- Article
- T-Cell Phenotypes and Systemic Cytokine Profiles of People Living with HIV Admitted to Hospital with COVID-19.Microorganisms · 2024Article
- Knowns and Unknowns about CAR-T Cell Dysfunction.Cancers · 2022Review
- Stage-Dependent Within-Individual Comparison Reveals SIV-Specific Activation/Exhaustion Shift in Rhesus Macaques.Frontiers in microbiology · 2021Article
- Genetic susceptibility to EBV infection: insights from inborn errors of immunity.Human genetics · 2020Review
- COVID-19: The Emerging Immunopathological Determinants for Recovery or Death.Frontiers in microbiology · 2020Review
- Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.Frontiers in immunology · 2020Review
- Bispecific antibodies: Potential immunotherapies for HIV treatment.Methods (San Diego, Calif.) · 2019Review
- Use of Mass Cytometry to Profile Human T Cell Exhaustion.Frontiers in immunology · 2019Review
- γδ T-cell responses during HIV infection and antiretroviral therapy.Clinical & translational immunology · 2019Review
- Phenotypic Evidence of T Cell Exhaustion and Senescence During SymptomaticFrontiers in immunology · 2019Article
- T Cell Therapy Targeted on HLA-A02 Restricted HIV Antigen Epitopes: An Open Label Cellular Therapy Trial Using CD8+ T Cell.Frontiers in immunology · 2019Article
- Review
- Quarter Century of Anti-HIV CAR T Cells.Current HIV/AIDS reports · 2018Review
- Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8Scientific reports · 2018Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies have revealed the critical role of programmed death-1 (PD-1) in exhaustion of HIV- and SIV-specific CD8(+) T cells. In this study, we show that high expression of PD-1 correlates with increased ex vivo spontaneous and CD95/Fas-induced apoptosis, particularly in the "effector-memory" CD8(+) T cell population from HIV(+) donors. High expression of PD-1 was linked to a proapoptotic phenotype characterized by low expression of Bcl-2 and IL7-R alpha, high expression of CD95/Fas and high mitochondrial mass. Expression of PD-1 and CD57 was differentially associated with the maturation status of CD8(+) T cells in HIV infection. CD57 was linked to higher apoptosis resistance, with cells expressing a PD-1(L)CD57(H) phenotype exhibiting lower levels of cell death. The majority of HIV-specific CD8(+) T cells were found to express a PD-1(H)CD57(L) or PD-1(H)CD57(H) phenotype. No correlation was found between PD-1 expression and ex vivo polyfunctionality of either HIV- or CMV-specific CD8(+) T cells. Contrary to CD57, high expression of PD-1 was characterized by translocation of PD-1 into the area of CD95/Fas-capping, an early necessary step of CD95/Fas-induced apoptosis. Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.