ArticlePediatrics2009
Intravenous lipid and bilirubin-albumin binding variables in premature infants.
Article in Pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Early versus late parenteral nutrition for critically ill term and late preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Early versus late parenteral nutrition in term and late preterm infants: a randomised controlled trial.BMJ paediatrics open · 2024Trial
- Bilirubin-albumin molar ratio for screening high unbound bilirubin across gestational ages.Pediatric research · 2026Observational
- Displacement of Bilirubin From Albumin by Omegaven and Intralipid.Journal of pediatric surgery · 2025Article
- Gut microbiota-regulated unconjugated bilirubin metabolism drives renal calcium oxalate crystal deposition.Gut microbes · 2025Article
- Sustained lower bilirubin-binding affinity of albumin in extremely preterm infants.Pediatric research · 2023Article
- Early versus late parenteral nutrition in term and late preterm infants: study protocol for a randomised controlled trial.BMC pediatrics · 2022Article
- The effect of different intravenous lipids on free bilirubin levels in premature infants.European journal of clinical nutrition · 2022Article
- Unbound bilirubin measurements by a novel probe in preterm infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019Article
- Effects of Soybean Lipid Infusion on Unbound Free Fatty Acids and Unbound Bilirubin in Preterm Infants.The Journal of pediatrics · 2017Article
- Bilirubin Binding Capacity in the Preterm Neonate.Clinics in perinatology · 2016Review
- Neonatal pharmacology: extensive interindividual variability despite limited size.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2011Article
- Newborn jaundice technologies: unbound bilirubin and bilirubin binding capacity in neonates.Seminars in perinatology · 2011Review
- Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants.Journal of perinatal medicine · 2011Article
- Effect of free fatty acids on bilirubin-albumin binding affinity and unbound bilirubin in premature infants.JPEN. Journal of parenteral and enteral nutritionArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe lipid intake at which a significant bilirubin-displacing effect occurs as a function of gestational age (GA) is unclear.
objectiveTo determine the effect of gradual increase in IL intake from 1.5 to 3 g/kg per day on bilirubin-albumin binding variables as a function of GA in premature infants with indirect hyperbilirubinemia.
methodsInfants of 24 to 33 weeks' gestation at birth who received IL (20% Intralipid [Fresenius Kabi, Uppsala, Sweden]) doses of 1.5, 2, 2.5, and 3 g/kg per day over 4 consecutive days were prospectively evaluated. The blood samples were drawn twice at least 8 hours apart on each IL intake to measure total serum bilirubin and free bilirubin by the peroxidase test. The highest free bilirubin on each IL intake, the corresponding total serum bilirubin, and serum albumin were used to calculate the bilirubin/albumin binding constant or binding affinity.
resultsSixty-two infants (median GA: 28 weeks) were studied during the first 10 days of life. None of the subjects had culture-proven sepsis, had triglyceride levels of >2.05 mmol/L, or were receiving steroids. Infants were grouped in 2-week GA intervals. The cumulative frequency of elevated free bilirubin concentration (>or=90th percentile or B(f) >or= 32 nmol/L) as a function of IL intake was inversely related to GA and was significantly different among 2-week GA groups. There was significant decrease in binding affinity and increase in free bilirubin concentration with higher IL intake for <or=28 week but not for >28 week GA groups.
conclusionsThe IL intake may be associated with a significant fall in the binding affinity of bilirubin for plasma protein and a concomitant increase in free bilirubin concentration in premature infants. The lipid intake at which this occurs depends on GA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.