ArticleFungal genetics and biology : FG & B2009
The Candida albicans histidine kinase Chk1p: signaling and cell wall mannan.
Article in Fungal genetics and biology : FG & B, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Novel structural features in Candida albicans hyphal glucan provide a basis for differential innate immune recognition of hyphae versus yeast.The Journal of biological chemistry · 2014Trial
- Osmotic Stress Responses, Cell Wall Integrity, and Conidiation Are Regulated by a Histidine Kinase Sensor inJournal of fungi (Basel, Switzerland) · 2023Article
- Integrated post-genomic cell wall analysis reveals floating biofilm formation associated with high expression of flocculins in the pathogen Pichia kudriavzevii.PLoS pathogens · 2023Article
- Multiple Genes of Candida albicans Influencing Echinocandin Susceptibility in Caspofungin-Adapted Mutants.Antimicrobial agents and chemotherapy · 2022Article
- Candida albicans CHK1 gene regulates its cross-kingdom interactions with Streptococcus mutans to promote caries.Applied microbiology and biotechnology · 2022Article
- Innate immune responses against the fungal pathogen Candida auris.Nature communications · 2022Article
- Deletion of Non-histidine Domains of Histidine KinaseFrontiers in microbiology · 2022Article
- Candida albicans CHK1 gene from two-component system is essential for its pathogenicity in oral candidiasis.Applied microbiology and biotechnology · 2021Article
- Sho1p Connects Glycolysis to Ras1-cAMP Signaling and Is Required for Microcolony Formation in Candida albicans.mSphere · 2020Article
- FDA Approved Drug Library Screening Identifies Robenidine as a Repositionable Antifungal.Frontiers in microbiology · 2020Article
- Mannan Molecular Substructures Control Nanoscale Glucan Exposure in Candida.Cell reports · 2018Article
- The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth ofFrontiers in microbiology · 2017Article
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- Cell Wall N-Linked Mannoprotein Biosynthesis Requires Goa1p, a Putative Regulator of Mitochondrial Complex I in Candida albicans.PloS one · 2016Article
- The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans.PloS one · 2015Article
- Iron-responsive chromatin remodelling and MAPK signalling enhance adhesion in Candida albicans.Molecular microbiology · 2014Article
- Two-component histidine phosphotransfer protein Ypd1 is not essential for viability in Candida albicans.Eukaryotic cell · 2014Article
- The Rbf1, Hfl1 and Dbp4 of Candida albicans regulate common as well as transcription factor-specific mitochondrial and other cell activities.BMC genomics · 2014Article
- Ser or Leu: structural snapshots of mistranslation in Candida albicans.Frontiers in molecular biosciences · 2014Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
Several published functions associated with the CHK1 histidine kinase of Candida albicans resemble those of the MAPK Cek1p and its cognate receptor Sho1p (SSU81). To explore this further, we have compared mutants lacking the proteins mentioned above and have constructed a double sho1/chk1Delta null mutant to determine relationships among these proteins. We observed that the sensitivity to Congo red (CR), calcofluor white (CW), as well as clumping of cells, was slightly increased in the double mutant compared to the single chk1Delta or sho1Delta mutants. However, Cek1p phosphorylation via Sho1p, which occurs during log phase growth in the presence or absence of CR in Wt cells, does not require Chk1p. These data suggest that Chk1p and Sho1p are components of parallel but independent signal pathways. In addition, bulk mannan of strains was analyzed by GLC/MS and GPC MALLS and NMR. Compared to Wt and a CHK1 gene-reconstituted strain (CHK23) that contained high, intermediate and low Mw mannan species, we found that the mannan of strains CHK21 (chk1Delta null), the cek1Delta null, and the double mutant consisted only of low Mw mannan. The sho1Delta null mutant only demonstrated a reduced intermediate type of mannan. Alcian blue binding was lower in cek1Delta, chk1Delta, and the double sho1/chk1Delta null mutant lacking high and intermediate Mw mannan than in the sho1Delta null which had a partial loss of intermediate Mw mannan only. We conclude that the Chk1p HK is part of a functionally similar but parallel pathway to the Sho1p-Cek1p pathway that confers resistance to the cell wall inhibitors CR and CW. However, a functional relationship in mannan biosynthesis of Chk1p and Cek1p exists that only partially requires Sho1p.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.