ArticleThe Journal of steroid biochemistry and molecular biology2009
Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells.
Article in The Journal of steroid biochemistry and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- Expression of Autophagy and Mitophagy Markers in Breast Cancer Tissues.Frontiers in oncology · 2021Article
- Article
- Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance.Cancer letters · 2019Review
- Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma.Antioxidants & redox signaling · 2016Article
- Article
- Article
- Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases.Antioxidants & redox signaling · 2014Review
- Progesterone induces the growth and infiltration of human astrocytoma cells implanted in the cerebral cortex of the rat.BioMed research international · 2014Article
- The requirement for p42/p44 MAPK activity in progesterone receptor-mediated gene regulation is target gene-specific.Steroids · 2013Article
- Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?Mitochondrion · 2013Review
- Effects of omega-3 fatty acids on progestin stimulation of invasive properties in breast cancer.Hormones & cancer · 2012Review
- Manganese superoxide dismutase (Sod2) and redox-control of signaling events that drive metastasis.Anti-cancer agents in medicinal chemistry · 2011Review
- Manganese superoxide dismutase: guardian of the powerhouse.International journal of molecular sciences · 2011Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Superoxide dismutase (SOD) occurs in two intracellular forms in mammals, copper-zinc SOD (CuZnSOD), found in the cytoplasm, mitochondria and nucleus, and manganese superoxide dismutase (MnSOD), in mitochondria. Changes in MnSOD expression (as compared to normal cells) have been reported in several forms of cancer, and these changes have been associated with regulation of cell proliferation, cell death, and metastasis. We have found that progestins stimulate MnSOD in T47D human breast cancer cells in a time and physiological concentration-dependent manner, exhibiting specificity for progestins and inhibition by the antiprogestin RU486. Progestin stimulation occurs at the level of mRNA, protein, and enzyme activity. Cycloheximide inhibits stimulation at the mRNA level, suggesting that progestin induction of MnSOD mRNA depends on synthesis of protein. Experiments with the MEK inhibitor UO126 suggest involvement of the MAP kinase signal transduction pathway. Finally, MnSOD-directed siRNA lowers progestin-stimulated MnSOD and inhibits progestin stimulation of migration and invasion, suggesting that up-regulation of MnSOD may be involved in the mechanism of progestin stimulation of invasive properties. To our knowledge, this is the first characterization of progestin stimulation of MnSOD in human breast cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.