ArticleExperimental gerontology2009
Age-dependent and gender-specific changes in mouse tissue iron by strain.
Article in Experimental gerontology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 98 citations in OpenAlex.
- Sex and Diet Biased Effect of L-DOPA on Iron Accumulation in the Ventral Midbrain.Journal of neurochemistry · 2026Article
- Article
- Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways to Age-Related Pathologies and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Comparison of methods for in vivo and ex vivo quantification of iron in murine brain tumors.PloS one · 2026Article
- Fractional curative killing of pyronaridine or artesunate combinations with tafenoquine, 4-aminoquinolines, or azithromycin in a murine malaria-luciferase model.Antimicrobial agents and chemotherapy · 2025Article
- Cethromycin pharmacokinetics and pharmacodynamics for single dose cure ofAntimicrobial agents and chemotherapy · 2025Article
- Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy.Aging and disease · 2025Review
- Stratification of the Extent of Visual Impairment Identifies Sex-Specific Degenerative Changes in Retinal Structure and Function during Aging.Journal of integrative neuroscience · 2025Article
- Alterations in iron levels in the locus coeruleus of a transgenic Alzheimer's disease rat model.Neuroscience letters · 2025Article
- The relationship between whole blood iron and fasting blood glucose in community-dwelling elderly people: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Knockdown of microglial iron import gene, Slc11a2, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease.Journal of neuroinflammation · 2024Article
- How aging influences the gut-bone marrow axis and alters hematopoietic stem cell regulation.Heliyon · 2024Review
- Knockdown of microglial iron import gene, DMT1, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease.Research square · 2024Article
- An iron rheostat controls hematopoietic stem cell fate.Cell stem cell · 2024Article
- Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum.Metallomics : integrated biometal science · 2024Article
- Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States.Investigative ophthalmology & visual science · 2023Article
- Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium.International journal of molecular sciences · 2023Article
- Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB.Cell death & disease · 2022Article
- Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein.Fluids and barriers of the CNS · 2022Article
- Role of Iron in Aging Related Diseases.Antioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Iron is necessary for life but also a potent pro-oxidant implicated in the pathogenesis of age-related diseases. We sought to determine if iron levels change with age and by sex in various tissues from several commonly studied mouse strains. Brain, liver, heart, retina, and retinal pigment epithelium (RPE)/choroid were dissected from male and female mice of young adult (2-6 month old) and aged (16-19 month old) C57BL/6, DBA/2J, and BALB/c mice. Iron was quantified through a chromagen-based spectrophotometric method or through atomic absorption spectrophotometry for increased sensitivity. Brain, liver, and heart iron increased by 30-70% in aged vs. young adult groups of all strains, while retina and RPE/choroid iron had variable age-related changes. Significant gender differences were observed in BALB/c and DBA/2J strains. Males had as much as 2- to 3-fold more brain, RPE/choroid, and retinal iron, while females had as much as 2- to 3-fold more liver iron. There was no significant gender difference observed in heart iron. The different profiles of change between gender and among strains suggest that hormones and genetics influence iron regulation with aging. Future manipulation of iron levels in mice will test the role of iron in aging and disease, and the data reported herein will be essential in directing such manipulations.
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