ArticleCell2009
The juxtamembrane region of EGFR takes center stage.
Article in Cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Tyrosine kinases sample unique activation ensembles.bioRxiv : the preprint server for biology · 2026Article
- The use of intuitive AF-based modelling for the understanding of activation and signalling through insulin-like receptors.Frontiers in endocrinology · 2025Review
- A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation.Journal of experimental & clinical cancer research : CR · 2019Article
- Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.Biochimica et biophysica acta. Biomembranes · 2017Review
- Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system.PloS one · 2017Article
- Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: Insights from multiscale molecular dynamics simulations.Biochimica et biophysica acta · 2015Article
- Inhibition of EGFR, HER2 and HER3 signaling with AZD8931 alone and in combination with paclitaxel: phase i study in Japanese patients with advanced solid malignancies and advanced breast cancer.Investigational new drugs · 2014Article
- EGFR-dependent mechanisms in glioblastoma: towards a better therapeutic strategy.Cellular and molecular life sciences : CMLS · 2014Review
- Phase I, dose-finding study of AZD8931, an inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling, in patients with advanced solid tumors.Investigational new drugs · 2014Article
- Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- EGFR: tale of the C-terminal tail.Protein science : a publication of the Protein Society · 2013Article
- Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation.ACS chemical biology · 2012Article
- MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors.Cancer research · 2012Article
- β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.Molecular biology of the cell · 2011Article
- MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation.The Journal of biological chemistry · 2011Article
- EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment.Cancer research · 2011Article
- Effects of clinically relevant MPL mutations in the transmembrane domain revealed at the atomic level through computational modeling.PloS one · 2011Article
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1 author.
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Abstract
The activation process for the epidermal growth factor receptor (EGFR) involves formation of an asymmetric dimer of the tyrosine kinase domains. Jura et al. (2009) in this issue and Brewer et al. (2009) in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in stabilizing this dimer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.