ArticleArthritis research & therapy2009
Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synovia.
Article in Arthritis research & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors.Arthritis research & therapy · 2015Trial
- Associations between inflammation-related LL-37 with subgingival microbial dysbiosis in rheumatoid arthritis patients.Clinical oral investigations · 2022Article
- RNA Editing-Associated Post-Transcriptional Gene Regulation in Rheumatoid Arthritis.Bioinformatics and biology insights · 2022Article
- Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.Frontiers in immunology · 2021Observational
- Treatment patterns and achievement of the treat-to-target goals in a real-life rheumatoid arthritis patient cohort: data from 1317 patients.Therapeutic advances in musculoskeletal disease · 2020Article
- Synovial Tissue Heterogeneity in Rheumatoid Arthritis and Changes With Biologic and Targeted Synthetic Therapies to Inform Stratified Therapy.Frontiers in medicine · 2019Review
- Synovial Tissue: Turning the Page to Precision Medicine in Arthritis.Frontiers in medicine · 2019Review
- Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.Frontiers in immunology · 2018Article
- The clinical utility of gene expression examination in rheumatology.Mediterranean journal of rheumatology · 2017Review
- TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions.Nucleic acids research · 2017Article
- CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case-control study.Arthritis research & therapy · 2015Article
- CD38 and E2F transcription factor 2 have uniquely increased expression in rheumatoid arthritis synovial tissues.Clinical and experimental immunology · 2014Article
- Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation.Arthritis research & therapy · 2014Article
- Gene expression analysis in RA: towards personalized medicine.The pharmacogenomics journal · 2014Review
- Gene expression patterns in peripheral blood cells associated with radiographic severity in African Americans with early rheumatoid arthritis.Rheumatology international · 2013Article
- Article
- Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies.Pharmacogenomics and personalized medicine · 2010Article
- A systems biology approach to synovial joint lubrication in health, injury, and disease.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRheumatoid arthritis (RA) is a heterogeneous disease and its underlying molecular mechanisms are still poorly understood. Because previous microarray studies have only focused on long-standing (LS) RA compared to osteoarthritis, we aimed to compare the molecular profiles of early and LS RA versus control synovia.
methodsSynovial biopsies were obtained by arthroscopy from 15 patients (4 early untreated RA, 4 treated LS RA and 7 controls, who had traumatic or mechanical lesions). Extracted mRNAs were used for large-scale gene-expression profiling. The different gene-expression combinations identified by comparison of profiles of early, LS RA and healthy synovia were linked to the biological processes involved in each situation.
resultsThree combinations of 719, 116 and 52 transcripts discriminated, respectively, early from LS RA, and early or LS RA from healthy synovia. We identified several gene clusters and distinct molecular signatures specifically expressed during early or LS RA, thereby suggesting the involvement of different pathophysiological mechanisms during the course of RA.
conclusionsEarly and LS RA have distinct molecular signatures with different biological processes participating at different times during the course of the disease. These results suggest that better knowledge of the main biological processes involved at a given RA stage might help to choose the most appropriate treatment.
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