ArticleInternational journal of experimental pathology2009
A detailed microscopic study of the changes in the aorta of experimental model of postmenopausal rats fed with repeatedly heated palm oil.
Article in International journal of experimental pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Blood Pressure Control Among Diabetic Patients in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis.Current diabetes reviews · 2025Pooled it
- Atherosclerosis and Insulin Resistance: Is There a Link Between Them?Biomedicines · 2025Review
- Evaluation of the Relationship between Presternal Fatty Tissue Thickness, Epicardial Fatty Tissue Volume, and Coronary Artery Disease.Current medical imaging · 2025Article
- Feeding rats with used cooking oil elevates malondialdehyde, TNF-α, and creatinine compared toNarra J · 2024Article
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- The Nutraceutical Properties of "Pizza Napoletana Marinara TSG" a Traditional Food Rich in Bioaccessible Antioxidants.Antioxidants (Basel, Switzerland) · 2021Article
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- Vascular Protective Effects ofInternational journal of vascular medicine · 2018Article
- Animal Models in Cardiovascular Research: Hypertension and Atherosclerosis.BioMed research international · 2015Review
- Reheated palm oil consumption and risk of atherosclerosis: evidence at ultrastructural level.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Effect of repeatedly heated palm olein on blood pressure-regulating enzymes activity and lipid peroxidation in rats.The Malaysian journal of medical sciences : MJMS · 2012Article
- The effects of heated vegetable oils on blood pressure in rats.Clinics (Sao Paulo, Brazil) · 2011Article
- Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Fresh soy oil protects against vascular changes in an estrogen-deficient rat model: an electron microscopy study.Clinics (Sao Paulo, Brazil) · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypercholesterolaemia, increase in lipid peroxidation and hyperhomocysteinaemia may contribute to the pathogenesis of atherosclerosis. This study was performed to examine the effects of repeatedly heated palm oil mixed with 2% cholesterol diet on atherosclerosis in oestrogen-deficient postmenopausal rats. Ovariectomy causes disruption of tunica intima layer of the rat aorta simulating a postmenopausal condition in females. Twenty-four ovariectomized female Sprague-Dawley rats were divided into four groups. The control group received 2% cholesterol diet without palm oil. A diet with 2% cholesterol content fortified with fresh, once-heated and five-times-heated palm oil was given to the other treatment groups. The rats were sacrificed at the end of 4 months of study and the aortic arch tissue was processed for histomorphometry and electron microscopy. On observation, there was disruption of the intimal layer of the ovariectomized rat aorta. There was no obvious ultrastructural change in the aorta of the rats fed with fresh palm oil. The ultrastructural changes were minimal with once-heated palm oil, in which there was a focal disruption of the endothelial layer. The focal disruption was more pronounced with five-times-heated palm oil. The results of this study show that the ingestion of fresh palm oil may have a protective effect on the aorta but such a protective action may be lost when the palm oil is repeatedly heated. The study may be clinically important for all postmenopausal women who are susceptible to atherosclerosis.
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