ReviewNephrology (Carlton, Vic.)2009
Review article: Biomarkers of clinical outcomes in advanced chronic kidney disease.
Review in Nephrology (Carlton, Vic.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Anemia and associated clinical outcomes in patients with heart failure due to reduced left ventricular systolic function.Clinical cardiology · 2013Trial
- The effect of high-flux hemodialysis on hemoglobin concentrations in patients with CKD: results of the MINOXIS study.Clinical journal of the American Society of Nephrology : CJASN · 2012Trial
- Impact of reduced kidney function on cardiopulmonary fitness in patients with systolic heart failure.American journal of nephrology · 2010Trial
- The FIB-4 Index Is Independently Associated with QTc Interval in Patients with Ankylosing Spondylitis.Journal of clinical medicine · 2026Article
- Dynamic hemoglobin trajectories and mortality in hemodialysis patients: a joint modeling study with iron and phosphorus markers.Frontiers in medicine · 2026Article
- Social capital and its association with clinically significant depressive symptoms in patients with end-stage kidney disease in Mexico.BMC public health · 2025Article
- Is anaemia associated with QTc prolongation? A retrospective cross-sectional analysis from a rural population-based cohort.BMJ open · 2025Observational
- Data Mining and Network Pharmacology Analysis of Kidney-Tonifying Herbs on the Treatment of Renal Osteodystrophy Based on the Theory of "Kidney Governing Bones" in Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Muscle Status Response to Oral Nutritional Supplementation in Hemodialysis Patients With Protein Energy Wasting: A Multi-Center Randomized, Open Label-Controlled Trial.Frontiers in nutrition · 2021Article
- Variability of laboratory parameters is associated with frailty markers and predicts non-cardiac mortality in hemodialysis patients.Clinical and experimental nephrology · 2015Observational
- Association of Serum Ig Free Light Chains with Mortality and ESRD among Patients with Nondialysis-Dependent CKD.Clinical journal of the American Society of Nephrology : CJASN · 2015Observational
- Protein carbamylation predicts mortality in ESRD.Journal of the American Society of Nephrology : JASN · 2013Article
- Secreted klotho and chronic kidney disease.Advances in experimental medicine and biology · 2012Review
- High platelet count as a link between renal cachexia and cardiovascular mortality in end-stage renal disease patients.The American journal of clinical nutrition · 2011Article
- Quantitative and qualitative urinary cellular patterns correlate with progression of murine glomerulonephritis.PloS one · 2011Article
- Racial and ethnic differences in mortality of hemodialysis patients: role of dietary and nutritional status and inflammation.American journal of nephrology · 2011Article
- The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis.Mayo Clinic proceedings · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic kidney disease (CKD) is a complex condition, where the decrease in kidney function is accompanied by numerous metabolic changes affecting virtually all the organ systems of the human body. Many of the biomarkers characteristic of the individually affected organ systems have been associated with adverse outcomes including higher mortality in advanced CKD, whereas in persons without CKD these biomarkers may have no bearing on survival. It is believed that the high mortality seen in CKD is a result of several abnormalities conspiring to induce or aggravate a heightened degree of cardiovascular morbidity and predisposition to wasting syndrome. Not all the biomarkers may, however, be causally responsible for the adverse outcomes associated with them. We review various biomarkers of protein-energy wasting, inflammation, oxidative stress, potassium disarrays, acid-base disorders, bone and mineral disorders, glycemic status, and anemia. Although all of these biomarkers have shown associations with worsened outcomes in CKD, markers of protein-energy wasting, especially serum albumin, remain the strongest predictor of survival in CKD patients, especially those undergoing maintenance dialysis treatment. We also review the putative pathophysiologic mechanisms behind these associations, and present potential therapeutic interventions that could result in remedies to improve poor clinical outcomes in CKD, pending the results of current and future controlled trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.