ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2009
Perception versus reality?: Virtual crossmatch--how to overcome some of the technical and logistic limitations.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 89 citations in OpenAlex.
- Impact of allele-specific anti-human leukocyte antigen class I antibodies on organ allocation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Virtual crossmatch for deceased donor kidney transplantation in the United States: A survey of histocompatibility lab directors and transplant surgeons.Human immunology · 2023Article
- Technical and clinical aspects of the histocompatibility crossmatch assay in solid organ transplantationBiomedica : revista del Instituto Nacional de Salud · 2022Article
- Positive flow cytometry crossmatch with discrepant antibody testing results following COVID-19 vaccination.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Trends and impact on cold ischemia time and clinical outcomes using virtual crossmatch for deceased donor kidney transplantation in the United States.Kidney international · 2021Article
- KPDGUI: An interactive application for optimization and management of a virtual kidney paired donation program.Computers in biology and medicine · 2019Article
- HLA in transplantation.Nature reviews. Nephrology · 2018Review
- Improvement in the definition of anti-HLA antibody profile in highly sensitized patients.PloS one · 2017Article
- Impact of preformed donor-specific antibodies against HLA class I on kidney graft outcomes: Comparative analysis of exclusively anti-CwWorld journal of transplantation · 2016Article
- A Novel Method for Anti-HLA Antibody Detection Using Personalized Peptide Arrays.Transplantation direct · 2016Article
- Antibody-mediated Rejection in Lung Transplantation.Current transplantation reports · 2015Article
- Interlaboratory Comparison of the Results of Lifecodes LSA Class I and Class II Single Antigen Kits for Human Leukocyte Antigen Antibody Detection.Annals of laboratory medicine · 2015Article
- Lung transplantation.F1000prime reports · 2013Article
- Surveillance of alloantibodies after transplantation identifies the risk of chronic rejection.Kidney international · 2011Article
- Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation.Journal of the American Society of Nephrology : JASN · 2010Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
The goal of this work was to evaluate concordance between (a) actual flow cytometric crossmatch (FCXM) that is performed by the OPO laboratory servicing our transplant center and (b) virtual XM (vXM) prediction based on antibody identification by solid-phase methods performed in our laboratory. A total of 1586 FCXM, performed between June 2007 and September 2008, between all potential deceased donors in our region and sera from patients awaiting kidney or kidney-pancreas transplant, listed at Northwestern Memorial Hospital were evaluated. A key finding of this analysis was the understanding that a thorough vXM cannot be performed in some donor/recipient pairs due to the lack of certain antibody profile data specific to the donor in question. Obtaining more in depth and stringent information regarding antibody specificities, we demonstrate an excellent sensitivity and specificity of the vXM assays- 86.1% and 96.8%, respectively, with a positive likelihood ratio and negative likelihood ratios of 26.9 and 0.14, respectively. The vXM can serve as an outstanding tool to predict HLA compatibility between donor and recipient, with the caveat that the presence/absence of all antibodies against the potential donor and their strength have been thoroughly investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.