ArticleTissue engineering. Part A2009
Tissue formation and vascularization in anatomically shaped human joint condyle ectopically in vivo.
Article in Tissue engineering. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 81 citations in OpenAlex.
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- Micro-thin hydrogel coating integrated in 3D printing for spatiotemporal delivery of bioactive small molecules.Biofabrication · 2024Article
- Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears.Bioactive materials · 2023Article
- Regeneration of Humeral Head Using a 3D Bioprinted Anisotropic Scaffold with Dual Modulation of Endochondral Ossification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Lidocaine inhibits osteogenic differentiation of human dental pulp stem cellsThe Journal of international medical research · 2023Article
- Review
- Stem cell homing in periodontal tissue regeneration.Frontiers in bioengineering and biotechnology · 2022Review
- Nanocelluloses - Nanotoxicology, Safety Aspects and 3D Bioprinting.Advances in experimental medicine and biology · 2022Review
- Review
- Regenerative Engineering: Current Applications and Future Perspectives.Frontiers in surgery · 2021Review
- Effect of local anesthetics on viability and differentiation of various adult stem/progenitor cells.Stem cell research & therapy · 2020Article
- In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells.Biofabrication · 2019Article
- Effect of dose and release rate of CTGF and TGFβ3 on avascular meniscus healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- A Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury.Theranostics · 2019Article
- Preclinical Animal Models for Temporomandibular Joint Tissue Engineering.Tissue engineering. Part B, Reviews · 2018Review
- Engineered Healing of Avascular Meniscus Tears by Stem Cell Recruitment.Scientific reports · 2018Article
- Printing of Three-Dimensional Tissue Analogs for Regenerative Medicine.Annals of biomedical engineering · 2017Review
- Bone Graft Prefabrication Following the In Vivo Bioreactor Principle.EBioMedicine · 2016Review
- Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones.Clinical biomechanics (Bristol, Avon) · 2015Article
- Biological and MRI characterization of biomimetic ECM scaffolds for cartilage tissue regeneration.Biomaterials · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Scale-up of bioengineered grafts toward clinical applications is a challenge in regenerative medicine. Here, we report tissue formation and vascularization of anatomically shaped human tibial condyles ectopically with a dimension of 20 x 15 x 15 mm(3). A composite of poly-epsilon-caprolactone and hydroxyapatite was fabricated using layer deposition of three-dimensional interlaid strands with interconnecting microchannels (400 microm) and seeded with human bone marrow stem cells (hMSCs) with or without osteogenic differentiation. An overlaying layer (1 mm deep) of poly(ethylene glycol)-based hydrogel encapsulating hMSCs or hMSC-derived chondrocytes was molded into anatomic shape and anchored into microchannels by gel infusion. After 6 weeks of subcutaneous implantation in athymic rats, hMSCs generated not only significantly more blood vessels, but also significantly larger-diameter vessels than hMSC-derived osteoblasts, although hMSC-derived osteoblasts yielded mineralized tissue in microchannels. Chondrocytes in safranin-O-positive glycosaminoglycan matrix were present in the cartilage layer seeded with hMSC-derived chondrogenic cells, although significantly more cells were present in the cartilage layer seeded with hMSCs than hMSC-derived chondrocytes. Together, MSCs elaborate substantially more angiogenesis, whereas their progenies yield corresponding differentiated tissue phenotypes. Scale up is probable by incorporating a combination of stem cells and their progenies in repeating modules of internal microchannels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.