ArticleLangmuir : the ACS journal of surfaces and colloids2009
C2AB: a molecular glue for lipid vesicles with a negatively charged surface.
Article in Langmuir : the ACS journal of surfaces and colloids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Systematic Targeting of Protein Complexes with Molecular COUPLrs.Cancer discovery · 2026Article
- A Suitable Membrane Distance Regulated by the RBD_ACE2 Interaction is Critical for SARS-CoV-2 Spike-Mediated Viral Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Double-Transmembrane Domain of SNAREs Decelerates the Fusion by Increasing the Protein-Lipid Mismatch.Journal of molecular biology · 2023Article
- Lipid Species Dependent Vesicles Clustering Caused by alpha-Synuclein as Revealed by Single-Vesicle Imaging with Total Internal Reflection Fluorescence Microscopy.Biophysics reports · 2021Article
- Single-vesicle measurement of protein-induced membrane tethering.Colloids and surfaces. B, Biointerfaces · 2019Article
- Calcium-dependent molecular fMRI using a magnetic nanosensor.Nature nanotechnology · 2018Article
- Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.Frontiers in molecular neuroscience · 2017Article
- High Transmembrane Voltage Raised by Close Contact Initiates Fusion Pore.Frontiers in molecular neuroscience · 2016Article
- Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion.Physical biology · 2015Article
- Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Scientific reports · 2015Article
- Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding.Biochemistry · 2014Article
- Synaptotagmin 1 and Ca2+ drive trans SNARE zippering.Scientific reports · 2014Article
- The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening.The Biochemical journal · 2013Article
- Prevalent mechanism of membrane bridging by synaptotagmin-1.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Nanochannel-based single molecule recycling.Nano letters · 2012Article
- A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins.Nature protocols · 2012Article
- Single-molecule FRET study of SNARE-mediated membrane fusion.Bioscience reports · 2011Review
- Mechanism and function of synaptotagmin-mediated membrane apposition.Nature structural & molecular biology · 2011Article
- Single vesicle assaying of SNARE-synaptotagmin-driven fusion reveals fast and slow modes of both docking and fusion and intrasample heterogeneity.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Artificial particulate systems such as lipid vesicles are found in a variety of biomedical applications such as drug delivery and targeting. More versatile layers of control would be added if liposomes could be glued together on demand while stabilized against fusion. Here, we present a two-component molecular glue composed of a protein and calcium ions, with each component specialized for fast and specific binding to negatively charged lipid membranes. Upon mixing the two components, the high affinity binding of this glue starts to tightly bridge two lipid vesicles on a subsecond scale. Furthermore, highly charged liposomes are beneficial in preventing spontaneous fusion before applying the molecular glue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.