ArticleWiener klinische Wochenschrift2009
Preoperative total serum cholesterol as a prognostic factor for survival in patients with resectable non-small-cell lung cancer.
Article in Wiener klinische Wochenschrift, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Controlling nutritional status score predicts clinical outcome in cancer patients treated with immune checkpoint inhibitor: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Blood lipid metabolic biomarkers are emerging as significant prognostic indicators for survival in cancer patients.BMC cancer · 2024Pooled it
- The Prognostic Value of Preoperative Total Cholesterol in Surgically Treated Oral Cavity Cancer.Biomedicines · 2024Article
- Pre-existing cardiometabolic comorbidities and survival of middle-aged and elderly non-small cell lung cancer patients.Journal of geriatric cardiology : JGC · 2023Article
- Untargeted Lipidomics of Non-Small Cell Lung Carcinoma Demonstrates Differentially Abundant Lipid Classes in Cancer vs. Non-Cancer Tissue.Metabolites · 2021Article
- Prognostic significance of preoperative serum triglycerides and high-density lipoproteins cholesterol in patients with non-small cell lung cancer: a retrospective study.Lipids in health and disease · 2021Article
- [Research Progress on the Relationship between Blood Lipids and Lung Cancer Risk and Prognosis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020Review
- A nomogram to predict outcomes of lung cancer patients after pneumonectomy based on 47 indicators.Cancer medicine · 2020Article
- The Molecular Mechanism of Metabolic Remodeling in Lung Cancer.Journal of Cancer · 2020Review
- CONUT Score or/and Peripheral Blood CD4+/CD8+ Ratio-Based Web Dynamic Nomograms to Predict the Individualized Survival of Patients with Advanced Osteosarcoma.Cancer management and research · 2020Article
- Clinical significance of pre-surgical serum lipid levels in patients with glioblastoma.Oncotarget · 2017Article
- Article
- Decreased pretreatment serum cholesterol level is related with poor prognosis in resectable non-small cell lung cancer.International journal of clinical and experimental pathology · 2015Article
- Article
- Impact of coexisting pulmonary diseases on survival of patients with lung adenocarcinoma: a STROBE-compliant article.Medicine · 2015Article
- Serum adiponectin relates to shortened overall survival in men with squamous cell esophageal cancer treated with preoperative concurrent chemoradiotherapy: a pilot study.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Preoperative Total Serum Cholesterol and Patients' Survival in Resected Nonsmall Cell Lung Cancer.Lung cancer international · 2012Article
- Risk factors and clinical courses of chemoradiation-related arterio-esophageal fistula in esophageal cancer patients with clinical invasion of the aorta.International journal of clinical oncology · 2011Article
- COPD is not COPD is not allergy.Wiener klinische Wochenschrift · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoexisting hypocholesterolemia in cancer has been known for a very long time but its relationship to cancer is still controversial. Hypocholesterolemia has been reported in patients with lung cancer, although its association with survival has not been explored.
objectivesThe purpose of the study was to determine whether preoperative total serum cholesterol is a prognostic factor for survival after lung cancer resection.
methodsThe retrospective study comprised 198 patients (162 men, 36 women) operated upon for resectable non-small-cell lung cancer (clinical stages I-IIIB) between January 1992 and April 1994. Total serum cholesterol concentration was determined preoperatively in each patient. The effects of sex, age, stage, histological type and preoperative total serum cholesterol concentration on survival were tested in univariate and multivariate analysis.
resultsPreoperative total serum cholesterol was a significant prognostic factor in both univariate and multivariate analysis. The median value for total serum cholesterol was 5.3 mmol/l and patients below that cut-off had significantly shorter overall survival times than patients in the high cholesterol group (5-year survival 41% vs. 56%, P < 0.05). In a multivariate Cox proportional-hazard regression model, only stage and preoperative total serum cholesterol were found to be of significance for survival (relative risk 0.84 for each mmol/l increase in concentration, CI 0.71-1.00, P < 0.05).
conclusionsOur results suggest that preoperative total serum cholesterol may be an important prognostic factor for overall survival after lung cancer resection. It may prove to be a valuable tool in the follow-up of patients with lung cancer and in detection of high-risk cases.
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