Evidence map›Paper›PMID 19562106›Full record

ReviewMolecular bioSystems2009

Biocomputers: from test tubes to live cells.

Yaakov Benenson

Abstract readReview
In one paragraph

Review in Molecular bioSystems, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. DNA-Based Dynamic Reaction Networks.Trends in biochemical sciences · 2018
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Implementation of Arithmetic Functions on a Simple and Universal Molecular Beacon Platform.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2015
    Article
  12. Nucleic acid based logical systems.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014
    Article
  13. Article
  14. Article
  15. Scaling down DNA circuits with competitive neural networks.Journal of the Royal Society, Interface · 2013
    Article
  16. The biological microprocessor, or how to build a computer with biological parts.Computational and structural biotechnology journal · 2013
    Review
  17. Logic reversibility and thermodynamic irreversibility demonstrated by DNAzyme-based Toffoli and Fredkin logic gates.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  18. Article
  19. The molecular basis of memory.ACS chemical neuroscience · 2012
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Yaakov BenensonFAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA. kbenenson@cgr.harvard.edu

Funding

THEORETICAL ANALYSIS OF FUNCTIONAL MODULESP50GM068763 · NIGMS · HARVARD UNIVERSITY · PI BENENSON, YAAKOV · 2003 to 2012
$28.9M
NIGMS NIH HHS GM068763NIGMS NIH HHS P50 GM068763
6 · The paper itself

Abstract

Biocomputers are man-made biological networks whose goal is to probe and control biological hosts--cells and organisms--in which they operate. Their key design features, informed by computer science and engineering, are programmability, modularity and versatility. While still a work in progress, biocomputers will eventually enable disease diagnosis and treatment with single-cell precision, lead to "designer" cell functions for biotechnology, and bring about a new generation of biological measurement tools. This review describes the intellectual foundation of the "biocomputer" concept as well as surveys the state of the art in the field.

Indexed as

Computers, MolecularBiotechnologyCell Physiological PhenomenaLogicModels, MolecularNucleic AcidsProteinsNucleic AcidsProteins

Identifiers

PMID19562106
PMCPMC2714485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.