ReviewDeutsches Arzteblatt international2009
Lyme disease--current state of knowledge.
Review in Deutsches Arzteblatt international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Spatiotemporal and tissue-specific dynamics of bacterial communities in adult femaleFrontiers in cellular and infection microbiology · 2026Article
- Antigenicity and immunogenicity of different morphological forms of Borrelia burgdorferi sensu lato spirochetes.Scientific reports · 2024Article
- Knowledge, Attitudes, and Behaviors Regarding Lyme Borreliosis Prevention in the Endemic Area of Northeastern Poland.Vaccines · 2022Article
- Role of Zoo-Housed Animals in the Ecology of Ticks and Tick-Borne Pathogens-A Review.Pathogens (Basel, Switzerland) · 2021Review
- The Diagnosis and Treatment of Idiopathic Facial Paresis (Bell's Palsy).Deutsches Arzteblatt international · 2019Review
- Cytokine Expression Patterns and Single Nucleotide Polymorphisms (SNPs) in Patients with Chronic Borreliosis.Antibiotics (Basel, Switzerland) · 2019Article
- [Usefulness of serological studies for the early diagnosis of Lyme disease in Primary Health Care Centres].Atencion primaria · 2018Article
- Successful treatment of fulminant Lyme myocarditis with mechanical circulatory support in a young male adult: a case report.Croatian medical journal · 2017Article
- Article
- Multi-trophic interactions driving the transmission cycle of Borrelia afzelii between Ixodes ricinus and rodents: a review.Parasites & vectors · 2015Review
- Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis.Journal of translational medicine · 2015Article
- Integration of Ixodes ricinus genome sequencing with transcriptome and proteome annotation of the naïve midgut.BMC genomics · 2015Article
- Lyme carditis--diagnosis, treatment and prognosis.Deutsches Arzteblatt international · 2015Review
- Intraarticular corticosteroids in refractory childhood Lyme arthritis.Rheumatology international · 2014Article
- [Diagnosis and treatment of Lyme arthritis. Recommendations of the Pharmacotherapy Commission of the Deutsche Gesellschaft für Rheumatologie (German Society for Rheumatology)].Zeitschrift fur Rheumatologie · 2014Article
- Clinical features of 705 Borrelia burgdorferi seropositive patients in an endemic area of northern Italy.TheScientificWorldJournal · 2014Article
- Brainstem abnormalities and vestibular nerve enhancement in acute neuroborreliosis.BMC research notes · 2013Article
- A phylogenomic and molecular signature based approach for characterization of the phylum Spirochaetes and its major clades: proposal for a taxonomic revision of the phylum.Frontiers in microbiology · 2013Article
- Efficacy of a novel fipronil spot-on for the treatment and control of induced infestations of adult cat fleas (Ctenocephalides felis) and castor bean ticks (Ixodes ricinus) on cats.Parasitology research · 2013Article
- Lyme disease: review.Archives of medical science : AMS · 2012Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLyme disease is the most frequent tick-borne infectious disease in Europe. The discovery of the causative pathogen Borrelia burgdorferi in 1982 opened the way for the firm diagnosis of diseases in several clinical disciplines and for causal antibiotic therapy. At the same time, speculation regarding links between Borrelia infection and a variety of nonspecific symptoms and disorders resulted in overdiagnosis and overtreatment of suspected Lyme disease.
methodThe authors conducted a selective review of the literature, including various national and international guidelines.
resultsThe spirochete Borrelia burgdorferi sensu lato is present in approximately 5% to 35% of sheep ticks (Ixodes ricinus) in Germany, depending on the region. In contrast to North America, different genospecies are found in Europe. The most frequent clinical manifestation of Borrelia infection is erythema migrans, followed by neuroborreliosis, arthritis, acrodermatitis chronica atrophicans, and lymphocytosis benigna cutis. Diagnosis is made on the basis of the clinical symptoms, and in stages II and III by detection of Borrelia-specific antibodies. In adults erythema migrans is treated with doxycycline, in children with amoxicillin. The standard treatment of neuroborreliosis is third-generation cephalosporins.
conclusionsAfter appropriate antibiotic therapy, the outcome is favorable. In approximately 95% of cases neuroborreliosis is cured without long-term sequelae. When chronic borreliosis is suspected, other potential causes of the clinical syndrome must be painstakingly excluded.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.