ArticleAnnals of thoracic medicine2009
Diagnosis of latent tuberculosis: Can we do better?
Article in Annals of thoracic medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Delayed-Type Hypersensitivity toInternational journal of molecular sciences · 2026Pooled it
- Is latent tuberculosis infection challenging in Iranian health care workers? A systematic review and meta-analysis.PloS one · 2019Pooled it
- The prevalence of tuberculosis infection in India: A systematic review and meta-analysis.The Indian journal of medical researchPooled it
- Tuberculosis incidence among infected contacts detected through contact tracing of smear-positive patients.PloS one · 2019Trial
- Latent tuberculosis infection and diagnostic performance of the tuberculin skin test among type 2 diabetics in Sana'a city, Yemen.BMC infectious diseases · 2024Article
- Prevalence of Latent Tuberculosis Infection (LTBI) in Mexican Patients With Rheumatoid Arthritis (RA).Cureus · 2023Article
- The prevalence and risk factors for tuberculosis among healthcare workers in Yogyakarta, Indonesia.PloS one · 2023Article
- Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment.European journal of microbiology & immunology · 2022Review
- Review
- Comparison of Latent Tuberculosis Infections among General versus Tuberculosis Health Care Workers in Myanmar.Tropical medicine and infectious disease · 2020Article
- Latent Tuberculosis Infection among Healthcare Workers in Duhok Province: From Screening to Prophylactic Treatment.Tropical medicine and infectious disease · 2019Article
- A novel strategy for interpreting the T-SPOT.TB test results read by an ELISPOT plate imager.PloS one · 2019Article
- Article
- Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology.Immunological reviews · 2018Review
- Article
- Paradoxical response to osimertinib therapy in a patient with T790M-mutated lung adenocarcinoma.Molecular and clinical oncology · 2018Article
- Imaging of thoracic tuberculosis in children: current and future directions.Pediatric radiology · 2017Review
- Role of apoptosis and autophagy in tuberculosis.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Latent Tuberculosis Infection Among Immigrant and Refugee Children Arriving in the United States: 2010.Journal of immigrant and minority health · 2016Article
- Hepatic abscess as a paradoxical response to antituberculous chemotherapy for tubercular lymphadenitis.BMJ case reports · 2015Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Latent tuberculosis infection (LTBI) is often diagnosed by the tuberculin skin test (TST). The latter has several limitations with regard to its sensitivity and specificity. It may be positive in people with prior bacille Calmette-Guérin (BCG) vaccination or exposure to nontuberculous mycobacteria. False negative TST results frequently occur in patients with impaired T-cell function. Therefore TST results have to be interpreted taking into consideration the pretest risk of TB infection or reactivation. Recently, interferon gamma release assays (IGRA) were introduced for the diagnosis of LTBI. These include the T-SPOT-TB and the QuantiFERON((R))-TB Gold tests.These tests measure interferon gamma released in response to T-cell stimulation by specific Mycobacterium tuberculosis antigens. These tests have been shown to be more specific than the TST as they are not affected by BCG vaccination. Their sensitivity was similar to that of the TST and in some studies they correlated better with the degree of exposure. In immune-compromised patients their sensitivity was better than that of the TST. IGRA tests were shown to have better predictive value for the development of active disease among individuals with LTBI. These tests are expensive. Their most cost-effective utilization is as confirmatory tests in patients with positive TST results, particularly in areas with high rates of BCG vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.