Evidence map›Paper›PMID 19561788›Full record

ArticleHippokratia2009

The multi-hit process and the antagonistic roles of tumor necrosis factor-alpha and adiponectin in non alcoholic fatty liver disease.

S A Polyzos, J Kountouras, Ch Zavos

Registry-linked trialAbstract readCommentLetter
In one paragraph

Article in Hippokratia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01147523 (The Effect of Spironolactone and Vitamin E Versus Vitamin E on Serum Adipocytokines Levels in Patients With Biopsy-proven Nonalcoholic Fatty Liver Disease-A Phase II Study), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01147523 phase2completednot on this mapstarted 2010, after this paper: background citation

The Effect of Spironolactone and Vitamin E Versus Vitamin E on Serum Adipocytokines Levels in Patients With Biopsy-proven Nonalcoholic Fatty Liver Disease-A Phase II Study

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2010 to 2011Enrolled30ConditionsFatty Liver, SteatohepatitisArmsSpironolactone/Vitamin E
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Correlation of Adiponectin Gene PolymorphismsFrontiers in endocrinology · 2022
    Pooled it
  3. Review
  4. Article
  5. ROS-responsive MnOTheranostics · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Ghrelin and liver disease.Reviews in endocrine & metabolic disorders · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

S A Polyzos
J Kountouras
Ch Zavos

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adipocytokineadiponectinfree fatty acidsinsulin resistancenonalcoholic fatty liver diseasenonalcoholic steatohepatitistumor necrosis factor

Identifiers

PMID19561788
PMCPMC2683459
OpenAlexW2396088323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.