ArticleNature immunology2009
Mina, an Il4 repressor, controls T helper type 2 bias.
Article in Nature immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 116 citations in OpenAlex.
- Predicting role of Myc-induced nuclear antigen 53 in determining the development and severity of systemic lupus erythematosus.Frontiers in immunology · 2024Article
- Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells.Seminars in cancer biology · 2021Review
- The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity.The Journal of clinical investigation · 2019Article
- The small members of the JMJD protein family: Enzymatic jewels or jinxes?Biochimica et biophysica acta. Reviews on cancer · 2019Review
- Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway.PloS one · 2019Article
- The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease.Cellular and molecular life sciences : CMLS · 2018Review
- Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution.BMC evolutionary biology · 2018Article
- High IL-1α Production Was Induced in the WBN/Kob-Helminthologia · 2018Article
- A SNP uncoupling Mina expression from the TGFβ signaling pathway.Immunity, inflammation and disease · 2018Article
- Dysfunction of IKZF1/MYC/MDIG axis contributes to liver cancer progression through regulating H3K9me3/p21 activity.Cell death & disease · 2017Article
- Effector/memory CD4 T cells making either Th1 or Th2 cytokines commonly co-express T-bet and GATA-3.PloS one · 2017Article
- Development and validation of an Onchocerca ochengi microfilarial hamster model for onchocerciasis drug screens.BMC infectious diseases · 2016Article
- T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.Nature communications · 2016Article
- The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair.Oncotarget · 2015Article
- Oncoprotein mdig contributes to silica-induced pulmonary fibrosis by altering balance between Th17 and Treg T cells.Oncotarget · 2015Article
- Mina: a Th2 response regulator meets TGFβ.Current opinion in immunology · 2014Review
- Article
- Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle.Frontiers in physiology · 2014Review
- Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion.PloS one · 2014Article
- T helper cell polarization in healthy people: implications for cardiovascular disease.Journal of cardiovascular translational research · 2013Review
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
T helper type 2 (T(H)2) bias, which is the propensity of naive CD4(+) T cells to differentiate into interleukin 4 (IL-4)-secreting T(H)2 cells, is a genetic trait that affects susceptibility to infectious, autoimmune and allergic diseases. T(H)2 bias correlates with the amount of IL-4 initially secreted by newly activated helper T cells that feeds back positively through the pathway of the IL-4 receptor and the transcription factors STAT6 and GATA-3 to drive T(H)2 development. Here we identify Mina, a member of the jumonji C (JmjC) protein family, as a genetic determinant of T(H)2 bias. Mina specifically bound to and repressed the Il4 promoter. Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4(+) T cells led to Il4 derepression. Our findings collectively provide mechanistic insight into an Il4-regulatory pathway that controls helper T cell differentiation and genetic variation in T(H)2 bias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.