ArticleNucleic acids research2009
JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- The basal transcriptional activity of the murine Klf10 gene is regulated by the transcriptional factor JunB.Genes & genomics · 2021Article
- miR-363 Alleviates Detrusor Fibrosis via the TGF-β1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM.Molecular therapy. Nucleic acids · 2020Article
- The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes.Kidney international · 2019Article
- Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli.PLoS computational biology · 2019Article
- Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF -β Signaling.Journal of the American Heart Association · 2018Article
- STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis posttranscriptionally, and is essential for lung myofibroblast differentiation.Molecular biology of the cell · 2018Article
- PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.Nature communications · 2017Article
- Transforming growth factor-Biochemistry and biophysics reports · 2016Article
- Article
- Transcriptional control of cardiac fibroblast plasticity.Journal of molecular and cellular cardiology · 2016Review
- Matrix remodeling in systemic sclerosis.Seminars in immunopathology · 2015Review
- Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- Soluble CD26/Dipeptidyl Peptidase IV Enhances the Transcription of IL-6 and TNF-α in THP-1 Cells and Monocytes.PloS one · 2013Article
- Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer.PloS one · 2012Article
- High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.Molecular biology of the cell · 2011Article
- Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production.The Journal of cell biology · 2010Article
- Identification and characterization of the human xylosyltransferase I gene promoter region.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Transcriptional control of the genes coding for collagen type I is regulated by a complex interaction between a distal enhancer and a proximal promoter. In this study, we have dissected the molecular mechanism of this interaction by defining a specific sequence within the enhancer that respond in fibroblasts to transforming growth factor-beta (TGF-beta). We show that TGF-beta activates COL1A2 gene via a non-canonical (Smad-independent) signalling pathway, which requires enhancer/promoter co-operation. This interaction involves exchange of cJun/Jun B transcription factor occupancy of a critical enhancer site resulting in the stabilization of enhancer/promoter coalescence. Moreover, using transgenesis, we show that interference in this mechanism results in the abolition of COL1A2 fibroblast expression in vivo. These data are therefore relevant to the control of collagen type I in vivo both in embryonic development, in adult connective tissue homeostasis, and in tissue repair and scarring pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.