ReviewAmerican journal of physiology. Lung cellular and molecular physiology2009
Animal models of asthma.
Review in American journal of physiology. Lung cellular and molecular physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 176 citations in OpenAlex.
- Effect of physical training on airway inflammation in animal models of asthma: a systematic review.BMC pulmonary medicine · 2013Pooled it
- Anaemia and Maternal Iron Intakes in Pregnancy and Child Asthma: An Observational Analysis From a Longitudinal Cohort.Health science reports · 2026Article
- Physiological and immunological aspects of asthma: the guinea pig (Cavia porcellus) as a model of allergic asthma.Laboratory animal research · 2025Review
- Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD).Comprehensive Physiology · 2025Review
- A current review on animal models of anti-asthmatic drugs screening.Frontiers in pharmacology · 2025Review
- An updated and comprehensive review of the morphology, ethnomedicinal uses, phytochemistry, and pharmacological activity ofHeliyon · 2024Review
- Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones.Physiological genomics · 2024Article
- Preclinical models of maternal asthma and progeny outcomes: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Evaluate the safety of a novel photohydrolysis technology used to clean and disinfect indoor air: A murine study.PloS one · 2024Article
- More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?Experimental physiology · 2023Article
- Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.Inflammation · 2023Article
- Review
- Allergic Sensitization Driving Immune Phenotyping and Disease Severity in a Mouse Model of Asthma.Allergy, asthma & immunology research · 2023Article
- Radix Asteris: Traditional Usage, Phytochemistry and Pharmacology of An Important Traditional Chinese Medicine.Molecules (Basel, Switzerland) · 2022Review
- Different Phenotypes in Asthma: Clinical Findings and Experimental Animal Models.Clinical reviews in allergy & immunology · 2022Review
- Article
- Purified Native and Recombinant MajorJournal of fungi (Basel, Switzerland) · 2021Article
- A role for bronchial epithelial autotaxin in ventilator-induced lung injury.Intensive care medicine experimental · 2021Article
- Critical roles of regulatory B and T cells in helminth parasite-induced protection against allergic airway inflammation.Clinical and experimental immunology · 2019Article
- The Club Cell Marker SCGB1A1 Downstream of FOXA2 is Reduced in Asthma.American journal of respiratory cell and molecular biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Studies in animal models form the basis for much of our current understanding of the pathophysiology of asthma, and are central to the preclinical development of drug therapies. No animal model completely recapitulates all features of the human disease, however. Research has focused primarily on ways to generate allergic inflammation by sensitizing and challenging animals with a variety of foreign proteins, leading to an increased understanding of the immunological factors that mediate the inflammatory response and its physiological expression in the form of airways hyperresponsiveness. Animal models of exaggerated airway narrowing are also lending support to the notion that asthma may represent an abnormality of the airway smooth muscle. The mouse is now the species of choice for asthma research involving animals. This presents practical challenges for physiological study because the mouse is so small, but modern imaging methodologies, coupled with the forced oscillation technique for measuring lung mechanics, have allowed the asthma phenotype in mice to be precisely characterized.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.