ArticleThe Journal of biological chemistry2009
Mycobacterial phosphatidylinositol mannosides negatively regulate host Toll-like receptor 4, MyD88-dependent proinflammatory cytokines, and TRIF-dependent co-stimulatory molecule expression.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Zinc-limitedInfection and immunity · 2025Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Immunological hyporesponsiveness in tuberculosis: The role of mycobacterial glycolipids.Frontiers in immunology · 2022Review
- Co-cultured adventitious roots ofChinese herbal medicines · 2021Article
- Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis.International journal of molecular sciences · 2021Article
- Effects of Mycobacterium vaccae vaccine in a mouse model of tuberculosis: protective action and differentially expressed genes.Military Medical Research · 2020Article
- Host and Pathogen Communication in the Respiratory Tract: Mechanisms and Models of a Complex Signaling Microenvironment.Frontiers in medicine · 2020Review
- Extracellular Vesicles in Mycobacterial Infections: Their Potential as Molecule Transfer Vectors.Frontiers in immunology · 2019Review
- Microenvironment ofBioMed research international · 2019Article
- Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.The journal of physiological sciences : JPS · 2018Article
- Mycobacterial glycolipid Di-O-acyl trehalose promotes a tolerogenic profile in dendritic cells.PloS one · 2018Article
- TLR4-NOX2 axis regulates the phagocytosis and killing of Mycobacterium tuberculosis by macrophages.BMC pulmonary medicine · 2017Article
- New findings of Toll-like receptors involved in Mycobacterium tuberculosis infection.Pathogens and global health · 2017Review
- Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.Nature communications · 2016Article
- Ac2PIM-responsive miR-150 and miR-143 target receptor-interacting protein kinase 2 and transforming growth factor beta-activated kinase 1 to suppress NOD2-induced immunomodulators.The Journal of biological chemistry · 2015Article
- Sensing of Mycobacterium tuberculosis and consequences to both host and bacillus.Immunological reviews · 2015Review
- Highly purified mycobacterial phosphatidylinositol mannosides drive cell-mediated responses and activate NKT cells in cattle.Clinical and vaccine immunology : CVI · 2015Article
- Differential effects of Mycobacterium bovis--derived polar and apolar lipid fractions on bovine innate immune cells.Veterinary research · 2012Article
- Divergent effects of mycobacterial cell wall glycolipids on maturation and function of human monocyte-derived dendritic cells.PloS one · 2012Article
- GM-CSF priming drives bone marrow-derived macrophages to a pro-inflammatory pattern and downmodulates PGE2 in response to TLR2 ligands.PloS one · 2012Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium tuberculosis modulates host immune responses through proteins and complex glycolipids. Here, we report that the glycosylphosphatidylinositol anchor phosphatidyl-myo-inositol hexamannosides PIM(6) or PIM(2) exert potent anti-inflammatory activities. PIM strongly inhibited the Toll-like receptor (TLR4) and myeloid differentiation protein 88 (MyD88)-mediated release of NO, cytokines, and chemokines, including tumor necrosis factor (TNF), interleukin 12 (IL-12) p40, IL-6, keratinocyte-derived chemokine, and also IL-10 by lipopolysaccharide (LPS)-activated macrophages. This effect was independent of the presence of TLR2. PIM also reduced the LPS-induced MyD88-independent, TIR domain-containing adaptor protein inducing interferon beta (TRIF)-mediated expression of co-stimulatory receptors. PIM inhibited LPS/TLR4-induced NFkappaB translocation. Synthetic PIM(1) and a PIM(2) mimetic recapitulated these in vitro activities and inhibited endotoxin-induced airway inflammation, TNF and keratinocyte-derived chemokine secretion, and neutrophil recruitment in vivo. Mannosyl, two acyl chains, and phosphatidyl residues are essential for PIM anti-inflammatory activity, whereas the inosityl moiety is dispensable. Therefore, PIM exert potent antiinflammatory effects both in vitro and in vivo that may contribute to the strategy developed by mycobacteria for repressing the host innate immunity, and synthetic PIM analogs represent powerful anti-inflammatory leads.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.