ArticleJournal of vascular and interventional radiology : JVIR2009
Development of a VX2 pancreatic cancer model in rabbits: a pilot study.
Article in Journal of vascular and interventional radiology : JVIR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Large animal models for investigating the applications of photodynamic therapy.Zoological research · 2025Review
- Review
- Development of a novel castration-resistant orthotopic prostate cancer model in New Zealand White rabbit.The Prostate · 2022Article
- Article
- The rabbit as a behavioral model system for magnetic resonance imaging.Journal of neuroscience methods · 2018Article
- Induction of VX2 para-renal carcinoma in rabbits: generation of animal model for loco-regional treatments of solid tumors.Infectious agents and cancer · 2016Article
- Radio-frequency ablation-based studies on VX2rabbit models for HCC treatment.Infectious agents and cancer · 2016Review
- Perfusion CT estimates photosensitizer uptake and biodistribution in a rabbit orthotopic pancreatic cancer model: a pilot study.Academic radiology · 2015Article
- Functional magnetic resonance imaging in an animal model of pancreatic cancer.World journal of gastroenterology · 2010Article
- Theranostic nanoparticles for detection and treatment of pancreatic cancer.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
- Development, growth, propagation, and angiographic utilization of the rabbit VX2 model of liver cancer: a pictorial primer and "how to" guide.Diagnostic and interventional radiology (Ankara, Turkey)Review
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Authors and funding
16 authors.
Funding
Abstract
purposeAn animal model of pancreatic cancer that is large enough to permit imaging and catheterization would be desirable for interventional radiologists to develop novel therapies for pancreatic cancer. The purpose of this study was to test the hypothesis that the VX2 rabbit model of pancreatic cancer could be developed as a suitable platform to test future interventional therapies. MATERIALS AND
methodsThe authors implanted and grew three pancreatic VX2 tumors per rabbit in six rabbits. Magnetic resonance (MR) imaging was performed at 2 weeks to confirm tumor growth. At 3 weeks, the authors selectively catheterized the gastroduodenal artery under guidance of x-ray digital subtraction angiography (DSA). T2-weighted anatomic imaging, diffusion-weighted MR imaging, and transcatheter intraarterial perfusion (TRIP) MR imaging were then performed. After imaging, tumors were confirmed at necropsy and histopathologically. Tumor sizes at 2 and 3 weeks were compared with a paired t test (P = .05).
resultsVX2 pancreatic tumors were grown in all six rabbits. The difference between tumor sizes at 2 and 3 weeks (1.29 cm +/- 0.39 vs 1.91 cm +/- 0.50, respectively) was significant (P < .001). All tumors were confirmed to be located within pancreatic tissue via histopathologic analysis. DSA and TRIP MR imaging were successful in five rabbits. Diffusion-weighted and anatomic MR imaging were successful in all six rabbits.
conclusionsThe VX2 rabbit model of pancreatic cancer is feasible, as verified by imaging and pathologic correlation, and may be a suitable platform to test future interventional therapies.
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