ReviewJournal of molecular and cellular cardiology2010
Translational lessons from scarless healing of cutaneous wounds and regenerative repair of the myocardium.
Review in Journal of molecular and cellular cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Transcriptomic responses to wounding: meta-analysis of gene expression microarray data.BMC genomics · 2017Pooled it
- Computational model predicts paracrine and intracellular drivers of fibroblast phenotype after myocardial infarction.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- A review of the literature on cardiac electrical activity between fibroblasts and myocytes.Progress in biophysics and molecular biology · 2016Review
- Regeneration versus scarring in vertebrate appendages and heart.The Journal of pathology · 2016Review
- Purinergic signaling in early inflammatory events of the foreign body response: modulating extracellular ATP as an enabling technology for engineered implants and tissues.Tissue engineering. Part B, Reviews · 2014Review
- Cardiac to cancer: connecting connexins to clinical opportunity.FEBS letters · 2014Review
- Regulating inflammation using acid-responsive electrospun fibrous scaffolds for skin scarless healing.Mediators of inflammation · 2014Article
- The pharmacology of regenerative medicine.Pharmacological reviews · 2013Review
- Model systems for cardiovascular regenerative biology.Cold Spring Harbor perspectives in medicine · 2013Review
- A Connexin43 Mimetic Peptide Promotes Regenerative Healing and Improves Mechanical Properties in Skin and Heart.Advances in wound care · 2013Review
- Embryonic wound healing: a primer for engineering novel therapies for tissue repair.Birth defects research. Part C, Embryo today : reviews · 2012Review
- The connexin43 carboxyl terminus and cardiac gap junction organization.Biochimica et biophysica acta · 2012Review
- Cardiac telocytes - their junctions and functional implications.Cell and tissue research · 2012Article
- The giant danio (D. aequipinnatus) as a model of cardiac remodeling and regeneration.Anatomical record (Hoboken, N.J. : 2007) · 2012Article
- Self-organizing tissue-engineered constructs in collagen hydrogels.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2012Article
- Granulocyte colony-stimulating factor treatment plus dipeptidylpeptidase-IV inhibition augments myocardial regeneration in mice expressing cyclin D2 in adult cardiomyocytes.European heart journal · 2012Article
- Extracellular matrix roles during cardiac repair.Life sciences · 2010Review
- Complex temporal regulation of capillary morphogenesis by fibroblasts.American journal of physiology. Cell physiology · 2010Article
- Understanding the role of the extracellular matrix in cardiovascular development and disease: where do we go from here?Journal of molecular and cellular cardiology · 2010Article
- Intramyocardial fibroblast myocyte communication.Circulation research · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Regenerative healing is the process by which injured tissues are restored to their original structure and function. Many species are capable of healing in this manner. However, in mammals the healing response in most tissues is marked by fibroblast proliferation and scar tissue deposition. While scarring contributes to efficient resolution of mammalian wounds and restoration of at least partial structural and functional support, the final result of scar formation can be more deleterious than the initial insult. This is especially true in the heart, which is sensitive to electrical heterogeneities and altered mechanical properties produced by scarring. Several therapeutic modalities promoting regeneration in skin wounds have been developed that modulate various aspects of the healing process. Targets include cytokine stimulation, control of fibroblast activation, modulation of gap junctions, and stem cell differentiation. Here, we review and compare mechanisms of injury, repair, and scarring in the skin and heart and discuss the promise and caveats of future therapies that may translate to improving repair of myocardial tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.