Evidence map›Paper›PMID 19560443›Full record

ArticleBrain research2010

Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis.

Ruchika Shaurya Prakash, Erin M Snook, Robert W Motl, Arthur F Kramer

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04097418 (Effects of Aerobic Training on Motor and Cognitive Performances in Patients With MS), which is not on this map. Cited by 82 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 9 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04097418 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Effects of Aerobic Training on Motor and Cognitive Performances in Patients With MS: an Exploratory Study With Structural and Functional MRI

TypeinterventionalSponsorIRCCS San RaffaeleRan2015 to 2024Enrolled80ConditionsMultiple SclerosisArmsAerobic training compared to conventional motor training
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 9 syntheses or guidelines pooled it, 214 citations in OpenAlex.

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  20. Role of Medicinal Plants in the Management of Multiple Sclerosis.Current pharmaceutical biotechnology · 2025
    Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ruchika Shaurya PrakashDepartment of Psychology, The Ohio State University, USA. prakash.30@osu.edu
Erin M Snook
Robert W Motl
Arthur F Kramer
University of Illinois Urbana-Champaign · USThe Ohio State University · USUniversity of Massachusetts Amherst · US

Funding

University of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3M
Influence of Fitness on Brain and CognitionR37AG025667 · NIA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI KRAMER, ARTHUR F. · 2005 to 2014
$5.1M
Aging and multi-task trainingR01AG025032 · NIA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI KRAMER, ARTHUR F. · 2005 to 2008
$1.2M
Influence of Fitness and Cognitive Training on Brain and CognitionR01AG025667 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MCAULEY, EDWARD · 2015 to 2015
$497k
NCRR NIH HHS UL1 RR025755NIA NIH HHS R01 AG025032NIA NIH HHS R01 AG025667NIA NIH HHS R01 AG25032NIA NIH HHS R01AG25667NIA NIH HHS R37 AG025667
6 · The paper itself

Abstract

Alterations in gray and white matter have been well documented in individuals with multiple sclerosis. Severity and extent of such brain tissue damage have been associated with cognitive impairment, disease duration and neurological disability, making quantitative indices of tissue damage important markers of disease progression. In this study, we investigated the association between cardiorespiratory fitness and measures of gray matter atrophy and white matter integrity. Employing voxel-based approaches to analysis of gray matter and white matter, we specifically examined whether higher levels of fitness in multiple sclerosis participants were associated with preserved gray matter volume and integrity of white matter. We found a positive association between cardiorespiratory fitness and regional gray matter volumes and higher focal fractional anisotropy values. Statistical mapping revealed that higher levels of fitness were associated with greater gray matter volume in the midline cortical structures including the medial frontal gyrus, anterior cingulate cortex and the precuneus. Further, we also found that increasing levels of fitness were associated with higher fractional anisotropy in the left thalamic radiation and right anterior corona radiata. Both preserved gray matter volume and white matter tract integrity were associated with better performance on measures of processing speed. Taken together, these results suggest that fitness exerts a prophylactic influence on the structural decline observed early on, preserving neuronal integrity in multiple sclerosis, thereby reducing long-term disability.

Indexed as

AdultAnimalsBrainDisease Models, AnimalExerciseExercise TherapyFemaleHumansMiddle AgedMultiple Sclerosis, Relapsing-RemittingNerve Fibers, MyelinatedPhysical FitnessTreatment Outcome

Identifiers

PMID19560443
PMCPMC2884046
OpenAlexW2020767502

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.