A histone code for regulating V(D)J recombination.

Mark S Schlissel, Danae Schulz, Christian Vettermann

Open access · bronzeAbstract readComment

In one paragraph

Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 43% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.Journal of immunology (Baltimore, Md. : 1950) · 2011
Article
The Igκ gene enhancers, E3' and Ed, are essential for triggering transcription.Journal of immunology (Baltimore, Md. : 1950) · 2010
Article

4 · The record

Corrections and comments

Comment on
H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.2009

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mark S SchlisselDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. mss@berkeley.edu

Danae Schulz

Christian Vettermann

University of California, Berkeley · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a recent issue of Molecular Cell, Shimazaki et al. (2009) show that an interaction between RAG2 and a methylated histone might play a critical regulatory role in V(D)J recombination by enhancing DNA binding and enzymatic activity of the V(D)J recombinase.

Indexed as

Models, GeneticRecombination, GeneticAnimalsBinding SitesDNA-Binding ProteinsDNA Breaks, Single-StrandedHistonesInverted Repeat SequencesMethylationMiceSubstrate SpecificityVDJ RecombinasesDNA-Binding ProteinsHistonesRag2 protein, mouseVDJ Recombinases

Identifiers

PMID19560416

DOI10.1016/j.molcel.2009.06.004

OpenAlexW2040615040

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.