ReviewTrends in cell biology2009
A quest for the mechanism regulating global planar cell polarity of tissues.
Review in Trends in cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 134 citations in OpenAlex.
- Systematic generation ofFly · 2026Article
- Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Review
- Wnt5a Regulates Embryonic Müllerian Duct Development Through the Non-Canonical Wnt PCP Pathway.Cells · 2026Article
- Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila.Cell reports · 2022Article
- Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity.Cold Spring Harbor perspectives in medicine · 2022Review
- Wnt-frizzled planar cell polarity signaling in the regulation of cell motility.Current topics in developmental biology · 2022Review
- Insights into Potential Targets for Therapeutic Intervention in Epilepsy.International journal of molecular sciences · 2020Review
- Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer.Clinical proteomics · 2020Article
- Polarity Establishment and Maintenance in Ascidian Notochord.Frontiers in cell and developmental biology · 2020Review
- Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos.Scientific reports · 2019Article
- Crumbs protein homolog 3 (CRB3) expression is associated with oestrogen and progesterone receptor positivity in breast cancer.Clinical and experimental pharmacology & physiology · 2019Article
- Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix.Development (Cambridge, England) · 2018Article
- Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.Development (Cambridge, England) · 2018Article
- Primary Cilia Reconsidered in the Context of Ciliopathies: Extraciliary and Ciliary Functions of Cilia Proteins Converge on a Polarity theme?BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment.PLoS genetics · 2018Article
- Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity.Development (Cambridge, England) · 2018Article
- From instruction to output: Wnt/PCP signaling in development and cancer.Current opinion in cell biology · 2018Review
- VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.Experimental cell research · 2017Article
- Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.Developmental biology · 2017Article
- Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5.Scientific reports · 2017Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Most epithelial cells, besides their ubiquitous apical-basal polarity, are polarized within the plane of the epithelium, which is called planar cell polarity (PCP). Using Drosophila as a model, meaningful progress has been made in the identification of key PCP factors and the dissection of their intracellular molecular interactions. The long-range, global aspects of coordinated polarization and the overlying regulatory mechanisms that create the initial polarity direction have, however, remained elusive. Several recent publications have outlined potential mechanisms of how the global regulation of PCP might be controlled and how the distinct core factor groups might interact via frizzled, Van Gogh or flamingo. This review focuses on these exciting features and attempts to provide an integrated picture of these recent and novel insights.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.