ArticlePain2009
Sex differences in functional brain activation during noxious visceral stimulation in rats.
Article in Pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Common brain activations for painful and non-painful aversive stimuli.BMC neuroscience · 2012Pooled it
- FAAH inhibitor URB597 shows anti-hyperalgesic action and increases brain and intestinal tissues fatty acid amides in a model of CRFNeurogastroenterology and motility · 2024Article
- Generation of a whole-brain hemodynamic response function and sex-specific differences in cerebral processing of mechano-sensation in mice detected by BOLD fMRI.Frontiers in neuroscience · 2023Article
- Olfactory Stimulation Successfully Modulates the Neurochemical, Biochemical and Behavioral Phenotypes of the Visceral Pain.Molecules (Basel, Switzerland) · 2022Article
- Sex differences in pain along the neuraxis.Neuropharmacology · 2022Review
- Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients.Frontiers in molecular neuroscience · 2022Article
- Activation of Infralimbic to Nucleus Accumbens Shell Pathway Suppresses Conditioned Aversion in Male But Not Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Sex differences in insular functional connectivity in response to noxious visceral stimulation in rats.Brain research · 2019Article
- Brain corticotropin-releasing factor signaling: Involvement in acute stress-induced visceral analgesia in male rats.Neurogastroenterology and motility · 2019Article
- Thalamic Cortical Error-Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Article
- Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats.Neurobiology of stress · 2016Article
- Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity.PloS one · 2016Article
- Estrogen-dependent visceral hypersensitivity following stress in rats: An fMRI study.Molecular pain · 2016Article
- Article
- Gender-related differences in irritable bowel syndrome: potential mechanisms of sex hormones.World journal of gastroenterology · 2014Review
- Article
- Sex differences and hormonal modulation of deep tissue pain.Frontiers in neuroendocrinology · 2013Review
- Amygdala functional connectivity is reduced after the cold pressor task.Cognitive, affective & behavioral neuroscience · 2013Article
- Sex differences in brain response to anticipated and experienced visceral pain in healthy subjects.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Studies in healthy human subjects and patients with irritable bowel syndrome suggest sex differences in cerebral nociceptive processing. Here we examine sex differences in functional brain activation in the rat during colorectal distention (CRD), a preclinical model of acute visceral pain. [(14)C]-iodoantipyrine was injected intravenously in awake, non-restrained female rats during 60- or 0-mmHg CRD while electromyographic abdominal activity (EMG) and pain behavior were recorded. Regional cerebral blood flow-related tissue radioactivity was analyzed by statistical parametric mapping from autoradiographic images of three-dimensionally reconstructed brains. Sex differences were addressed by comparing the current data with our previously published data collected from male rats. While sex differences in EMG and pain scores were modest, significant differences were noted in functional brain activation. Females showed widespread changes in limbic (amygdala, hypothalamus) and paralimbic structures (ventral striatum, nucleus accumbens, raphe), while males demonstrated broad cortical changes. Sex differences were apparent in the homeostatic afferent network (parabrachial nucleus, thalamus, insular and dorsal anterior cingulate cortices), in an emotional-arousal network (amygdala, locus coeruleus complex), and in cortical areas modulating these networks (prefrontal cortex). Greater activation of the ventromedial prefrontal cortex and broader limbic/paralimbic changes in females suggest greater engagement of affective mechanisms during visceral pain. Greater cortical activation in males is consistent with the concept of greater cortical inhibitory effects on limbic structures in males, which may relate to differences in attentional and cognitive attribution to visceral stimuli. These findings show remarkable similarities to reported sex differences in brain responses to visceral stimuli in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.