Trial reportBiological psychiatry2009
Dorsolateral prefrontal cortex activity predicts responsiveness to cognitive-behavioral therapy in schizophrenia.
Trial report in Biological psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 119 citations in OpenAlex.
- Brain connectomics markers for response prediction to transcranial magnetic stimulation in cocaine use disorder.Scientific reports · 2025Trial
- Internet addiction and functional brain networks: task-related fMRI study.Scientific reports · 2019Trial
- Towards personalized, brain-based behavioral intervention for transdiagnostic anxiety: Transient neural responses to negative images predict outcomes following a targeted computer-based intervention.Journal of consulting and clinical psychology · 2018Trial
- Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity.Translational psychiatry · 2017Trial
- The functional -1019C/G HTR1A polymorphism and mechanisms of fear.Translational psychiatry · 2014Trial
- Motor co-activation in siblings of patients with juvenile myoclonic epilepsy: an imaging endophenotype?Brain : a journal of neurology · 2014Trial
- Sensorimotor gating and clinical outcome following cognitive behaviour therapy for psychosis.Schizophrenia research · 2012Trial
- Neural changes following cognitive behaviour therapy for psychosis: a longitudinal study.Brain : a journal of neurology · 2011Trial
- Coping styles predict responsiveness to cognitive behaviour therapy in psychosis.Psychiatry research · 2011Trial
- Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis.Schizophrenia research · 2009Trial
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Brain Connectomics Improve the Prediction of High-Risk Depression Profiles in the First Year following Breast Cancer Diagnosis.Depression and anxiety · 2024Article
- Associations Between Brain Structural Connectivity and 1-Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study.Depression and anxiety · 2024Article
- Repetitive Transcranial Magnetic Stimulation for Working Memory Deficits in Schizophrenia: A Systematic Review of Randomized Controlled Trials.Neuropsychiatric disease and treatment · 2024Review
- Neuroimaging Mechanism of Cognitive Behavioral Therapy in Pain Management.Pain research & management · 2022Review
- Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography.Nature biomedical engineering · 2021Article
- Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia.Neural plasticity · 2021Observational
- Neuroimaging markers of antipsychotic treatment response in schizophrenia: An overview of magnetic resonance imaging studies.Neurobiology of disease · 2019Review
- Using fMRI and machine learning to predict symptom improvement following cognitive behavioural therapy for psychosis.NeuroImage. Clinical · 2018Article
- Mindboggling morphometry of human brains.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundGiven the variable response to cognitive-behavioral therapy (CBT) when added to antipsychotic medication in psychosis and the evidence for a role of pretherapy level of frontal lobe-based cognitive function in responsiveness to CBT in other disorders, this study examined whether pretherapy brain activity associated with working memory neural network predicts clinical responsiveness to CBT in schizophrenia.
methodsFifty-two outpatients stable on medication with at least one distressing symptom of schizophrenia and willing to receive CBT in addition to their usual treatment and 20 healthy participants underwent functional magnetic resonance imaging during a parametric n-back task. Subsequently, 26 patients received CBT for psychosis (CBT+treatment-as-usual [TAU], 19 completers) for 6-8 months, and 26 continued with TAU alone (17 completers). Symptoms in both patient groups were assessed (blindly) at entry and follow-up.
resultsThe CBT+TAU and TAU-alone groups did not differ clinically or in performance at baseline. The CBT+TAU group showed significant improvement in relation to the TAU-alone group, which showed no change, at follow-up. Stronger dorsolateral prefrontal cortex (DLPFC) activity (within the normal range) and DLPFC-cerebellum connectivity during the highest memory load condition (2-back > 0-back) were associated with post-CBT clinical improvement.
conclusionsDLPFC activity and its connectivity with the cerebellum predict responsiveness to CBT for psychosis in schizophrenia. These effects may be mediated by PFC-cerebellum contributions to executive processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.