ArticleEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2009
Selective removal of stratum corneum by microdermabrasion to increase skin permeability.
Article in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 83 citations in OpenAlex.
- Effect of Dextran-Aminated Hyaluronic Acid Hydrogel on the Repair of Different Degrees of Epidermal Injury.Journal of cosmetic dermatology · 2025Article
- Advancements in Skin-Mediated Drug Delivery: Mechanisms, Techniques, and Applications.Advanced healthcare materials · 2024Review
- Review
- Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment.AAPS PharmSciTech · 2023Article
- Nanoparticles for Topical Application in the Treatment of Skin Dysfunctions-An Overview of Dermo-Cosmetic and Dermatological Products.International journal of molecular sciences · 2022Review
- Effect of an Oxygen-Based Mechanical Drug Delivery System on Percutaneous Permeation of Various Substances In Vitro.Pharmaceutics · 2022Article
- Delivery of Insulin via Skin Route for the Management of Diabetes Mellitus: Approaches for Breaching the Obstacles.Pharmaceutics · 2021Review
- Review
- Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration.International journal of molecular sciences · 2020Review
- The potential role of using vaccine patches to induce immunity: platform and pathways to innovation and commercialization.Expert review of vaccines · 2020Review
- OxygeneoThe Journal of clinical and aesthetic dermatology · 2017Article
- Transdermal drug delivery: feasibility for treatment of superficial bone stress fractures.Drug delivery and translational research · 2015Review
- Cutaneous immunization: an evolving paradigm in influenza vaccines.Expert opinion on drug delivery · 2014Review
- Physicochemical modulation of skin barrier by microwave for transdermal drug delivery.Pharmaceutical research · 2013Article
- DNA vaccination in the skin using microneedles improves protection against influenza.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Delivery systems for intradermal vaccination.Current topics in microbiology and immunology · 2012Review
- Recovery of skin barrier after stratum corneum removal by microdermabrasion.AAPS PharmSciTech · 2011Article
- Transdermal insulin delivery using microdermabrasion.Pharmaceutical research · 2011Article
- Optimization of microdermabrasion for controlled removal of stratum corneum.International journal of pharmaceutics · 2011Article
- Enabling skin vaccination using new delivery technologies.Drug delivery and translational research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability. Although, microdermabrasion has been used for cosmetic treatment of skin for decades, no study has assessed the detailed effects of microdermabrasion conditions on the degree of skin tissue removal. Therefore, we histologically characterized the skin of rhesus macaques and human volunteers after microdermabrasion at different conditions. Using mobile tip microdermabrasion, an increase in the number of treatment passes led to greater tissue removal ranging from minimal effects to extensive damage to deeper layers of the skin. Of note, these data showed for the first time that at moderate microdermabrasion conditions selective yet full-thickness removal of stratum corneum could be achieved with little damage to deeper skin tissues. In the stationary mode of microdermabrasion, selective stratum corneum removal was not observed, but micro-blisters could be seen. Similar tissue removal trends were observed in human volunteers. As proof of concept for drug delivery applications, a model fluorescent drug (fluorescein) was delivered through microdermabraded skin and antibodies were generated against vaccinia virus after its topical application in monkeys. In conclusion, microdermabrasion can selectively remove full-thickness stratum corneum with little damage to deeper tissues and thereby increase skin permeability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.