ReviewBiochimica et biophysica acta2009
Epigenetic mechanisms in schizophrenia.
Review in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Association Between NOS1 Gene Polymorphisms and Schizophrenia in Asian and Caucasian Populations: A Meta-Analysis.Neuromolecular medicine · 2017Pooled it
- Meta-analysis of sex differences in gene expression in schizophrenia.BMC systems biology · 2016Pooled it
- Analysis of Normalizers and Neurodevelopment-Related microRNAs in the Prefrontal Cortex and in the Sperm of SHR Rats.International journal of molecular sciences · 2025Article
- Molecular Signatures of Schizophrenia and Insights into Potential Biological Convergence.International journal of molecular sciences · 2025Review
- The heart of the matter: Developing the whole child through community resources and caregiver relationships.Development and psychopathology · 2021Article
- Unveiling the Metabolic Profile of First-Episode Drug-Naïve Schizophrenia Patients: Baseline Characteristics of a Longitudinal Study Among Han Chinese.Frontiers in psychiatry · 2021Article
- Altered Signaling in CB1R-5-HT2AR Heteromers in Olfactory Neuroepithelium Cells of Schizophrenia Patients is Modulated by Cannabis Use.Schizophrenia bulletin · 2020Article
- DNA Methylation Analysis of the NR3C1 Gene in Patients with Schizophrenia.Journal of molecular neuroscience : MN · 2020Article
- Effects of Cannabis Use on the Protein and Lipid Profile of Olfactory Neuroepithelium Cells from Schizophrenia Patients Studied by Synchrotron-Based FTIR Spectroscopy.Biomolecules · 2020Article
- Expression of Behavioral Phenotypes in Genetic and Environmental Mouse Models of Schizophrenia.Frontiers in behavioral neuroscience · 2020Article
- Abnormal Brain-Derived Neurotrophic Factor Exon IX Promoter Methylation, Protein, and mRNA Levels in Patients with Major Depressive Disorder.Journal of clinical medicine · 2019Article
- Axon guidance pathway genes are associated with schizophrenia risk.Experimental and therapeutic medicine · 2018Article
- The Role of Cannabis within an Emerging Perspective on Schizophrenia.Medicines (Basel, Switzerland) · 2018Article
- An Update on Promising Biomarkers in Schizophrenia.Focus (American Psychiatric Publishing) · 2018Review
- Salivary biomarkers for the diagnosis and monitoring of neurological diseases.Biomedical journal · 2018Review
- Stress in the Educational System as a Potential Source of Epigenetic Influences on Children's Development and Behavior.Frontiers in behavioral neuroscience · 2018Review
- Differences in atypical resting-state effective connectivity distinguish autism from schizophrenia.NeuroImage. Clinical · 2018Article
- Immersion in altered experience: An investigation of the relationship between absorption and psychopathology.Consciousness and cognition · 2017Article
- MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?Current neuropharmacology · 2017Review
- Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia?Frontiers in neuroscience · 2017Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Epidemiological research suggests that both an individual's genes and the environment underlie the pathophysiology of schizophrenia. Molecular mechanisms mediating the interplay between genes and the environment are likely to have a significant role in the onset of the disorder. Recent work indicates that epigenetic mechanisms, or the chemical markings of the DNA and the surrounding histone proteins, remain labile through the lifespan and can be altered by environmental factors. Thus, epigenetic mechanisms are an attractive molecular hypothesis for environmental contributions to schizophrenia. In this review, we first present an overview of schizophrenia and discuss the role of nature versus nurture in its pathology, where 'nature' is considered to be inherited or genetic vulnerability to schizophrenia, and 'nurture' is proposed to exert its effects through epigenetic mechanisms. Second, we define DNA methylation and discuss the evidence for its role in schizophrenia. Third, we define posttranslational histone modifications and discuss their place in schizophrenia. This research is likely to lead to the development of epigenetic therapy, which holds the promise of alleviating cognitive deficits associated with schizophrenia.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.