ArticleNeurobiology of aging2011
Effects of age, genes, and pulse pressure on executive functions in healthy adults.
Article in Neurobiology of aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2015Pooled it
- Pulse pressure is associated with cognitive performance in Japanese non-demented population: a cross-sectional study.BMC neurology · 2022Article
- Subjective memory concerns, poor vascular health, and male sex predict exacerbated memory decline trajectories: An integrative data-driven class and prediction analysis.Neuropsychology · 2022Article
- Data-driven approaches to executive function performance and structure in aging: Integrating person-centered analyses and machine learning risk prediction.Neuropsychology · 2021Article
- A Multimodal Risk Network Predicts Executive Function Trajectories in Non-demented Aging.Frontiers in aging neuroscience · 2021Article
- Interaction of Catechol-O-methyltransferase ValBrain and behavior · 2020Article
- Association study of the functional Catechol-O-Methyltranferase (COMT) ValInternational journal of medical sciences · 2019Article
- Dopamine-dependent cognitive processes after menopause: the relationship between COMT genotype, estradiol, and working memory.Neurobiology of aging · 2018Article
- Prospective associations between pulse pressure and cognitive performance in Chinese middle-aged and older population across a 5-year study period.Alzheimer's research & therapy · 2018Article
- Alzheimer's Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health and Demographic Risk Markers.Frontiers in aging neuroscience · 2018Article
- Age differences in arterial and venous extra-cerebral blood flow in healthy adults: contributions of vascular risk factors and genetic variants.Brain structure & function · 2017Article
- Defining the Relationship Between Hypertension, Cognitive Decline, and Dementia: a Review.Current hypertension reports · 2017Review
- Risk-reducing Apolipoprotein E and Clusterin genotypes protect against the consequences of poor vascular health on executive function performance and change in nondemented older adults.Neurobiology of aging · 2016Article
- Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation.Neuropsychologia · 2016Article
- Is less really more: Does a prefrontal efficiency genotype actually confer better performance when working memory becomes difficult?Cortex; a journal devoted to the study of the nervous system and behavior · 2016Article
- Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study.Neuropsychology · 2016Article
- ApoE and pulse pressure interactively influence level and change in the aging of episodic memory: Protective effects among ε2 carriers.Neuropsychology · 2015Article
- IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults.Psychology and aging · 2014Article
- Neural mechanisms of discourse comprehension: a human lesion study.Brain : a journal of neurology · 2014Article
- The catechol-o-methyltransferase Val158 Met polymorphism modulates organization of regional cerebral blood flow response to working memory in adults.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Executive functions (EF) evidence significant age-related declines, but the mechanisms underpinning those changes are unclear. In this study, we focus on two potential sources of variation: a physiological indicator of vascular health, and genetic variants related to vascular functions. In a sample of healthy adults (n=158, ages 18-81), we examine the effects of age, pulse pressure, and two polymorphisms (comt val158met and ace insertion/deletion) on working memory and cognitive flexibility. Results indicate that in addition to often-replicated age differences, the alleles of two polymorphisms that promote vasoconstriction (comt val and ace D) and reduced availability of dopamine in neocortical synapses (comt val), negatively impact virtually all aspects of EF tasks that involve working memory. In some cases, suppression of cognitive performance is limited to men or necessitates a combination of both risk-associated alleles. After accounting for genetic and age-related variation, pulse pressure had no additional effect on EF. These findings suggest that in healthy adults, the effects of genetic risk factors significantly modulate the course of cognitive aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.