ArticleNeuroscience research2009
Methamphetamine treatment causes delayed decrease in novelty-induced locomotor activity in mice.
Article in Neuroscience research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Protective effects of alpha-lipoic acid on anxiety-like behavior, memory and prevention of hippocampal oxidative stress in methamphetamine-treated rats.Psychopharmacology · 2024Article
- Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.Acta pharmacologica Sinica · 2022Article
- Fragment C Domain of Tetanus Toxin Mitigates Methamphetamine Neurotoxicity and Its Motor Consequences in Mice.The international journal of neuropsychopharmacology · 2016Article
- Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways.Psychopharmacology · 2016Review
- Methamphetamine induces low levels of neurogenesis in striatal neuron subpopulations and differential motor performance.Neurotoxicity research · 2014Article
- GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum.Behavioural brain research · 2012Article
- Effects of exposure to amphetamine derivatives on passive avoidance performance and the central levels of monoamines and their metabolites in mice: correlations between behavior and neurochemistry.Psychopharmacology · 2012Article
- Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model.Neuropharmacology · 2012Article
- Mouse strain- and age-dependent effects of binge methamphetamine on dopaminergic signaling.Neurotoxicology · 2011Article
- Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain.PloS one · 2011Article
- Methamphetamine-induced locomotor changes are dependent on age, dose and genotype.Pharmacology, biochemistry, and behavior · 2011Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Methamphetamine (METH) is a psychostimulant that causes damage to dopamine (DA) axons and to non-monoaminergic neurons in the brain. The aim of the present study was to investigate short- and long-term effects of neurotoxic METH treatment on novelty-induced locomotor activity in mice. Male BALB/c mice, 12-14 weeks old, were injected with saline or METH (i.p., 7.5 mg/kg x 4 times, every 2 h). Behavior and neurotoxic effects were assessed at 10 days, 3 and 5 months following drug treatment. METH administration caused marked decreases in DA levels in the mouse striatum and cortex at 10 days post-drug. However, METH did not induce any changes in novelty-induced locomotor activity. At 3 and 5 months after treatment METH-exposed mice showed significant recovery of DA levels in the striatum and cortex. In contrast, these animals demonstrated significant decreases in locomotor activity at 5 months in comparison to aged-matched control mice. Further assessment of METH toxicity using TUNEL staining showed that the drug induced increased cell death in the striatum and cortex at 3 days after administration. Taken together, these data suggest that delayed deficits in novelty-induced locomotor activity observed in METH-exposed animals are not due to neurodegeneration of DA terminals but to combined effects of METH and age-dependent dysfunction of non-DA intrinsic striatal and/or corticostriatal neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.