ArticleFibrogenesis & tissue repair2009
Possible mechanisms of kidney repair.
Article in Fibrogenesis & tissue repair, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- HDAC4 drives ferroptosis and fibrosis by inhibiting Foxo3a-GPX4 axis during AKI-CKD progression.Research square · 2025Article
- Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary.Life medicine · 2024Article
- ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways.Journal of Zhejiang University. Science. B · 2024Article
- Treatment of Chronic Kidney Disease with Extracellular Vesicles from Mesenchymal Stem Cells and CD133International journal of molecular sciences · 2022Article
- Renal Interstitial Platelet-Derived Growth Factor Receptor-Journal of the American Society of Nephrology : JASN · 2018Article
- A population of mitochondrion-rich cells in the pars recta of mouse kidney.Cell and tissue research · 2016Article
- Comparative effects of mesenchymal stem cell therapy in distinct stages of chronic renal failure.Clinical and experimental nephrology · 2015Article
- WNT/β-Catenin Signaling Is Required for Integration of CD24+ Renal Progenitor Cells into Glycerol-Damaged Adult Renal Tubules.Stem cells international · 2015Article
- Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury.BioResearch open access · 2015Review
- Analysis of nephron composition and function in the adult zebrafish kidney.Journal of visualized experiments : JoVE · 2014Article
- New tides: using zebrafish to study renal regeneration.Translational research : the journal of laboratory and clinical medicine · 2014Review
- Can kidney regeneration be visualized?Nephron. Experimental nephrology · 2014Review
- Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress.American journal of physiology. Renal physiology · 2013Article
- Histone deacetylase inhibitor enhances recovery after AKI.Journal of the American Society of Nephrology : JASN · 2013Article
- Renal stem cells: fact or science fiction?The Biochemical journal · 2012Review
- The Role of PEC Progenitors in ADPKD Progression.International journal of stem cells · 2012Article
- Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes.Pediatric nephrology (Berlin, Germany) · 2011Article
- Zebrafish kidney development: basic science to translational research.Birth defects research. Part C, Embryo today : reviews · 2011Review
- Glomerular parietal epithelial cells of adult murine kidney undergo EMT to generate cells with traits of renal progenitors.Journal of cellular and molecular medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most adult epithelia the process of replacing damaged or dead cells is maintained through the presence of stem/progenitor cells, which allow epithelial tissues to be repaired following injury. Existing evidence strongly supports the presence of stem cells in the adult kidney. Indeed, recent findings provide evidence in favour of a role for intrinsic renal cells and against a physiological role for bone marrow-derived stem cells in the regeneration of renal epithelial cells. In addition, recent studies have identified a subset of CD24+CD133+ renal progenitors within the Bowman's capsule of adult human kidney, which provides regenerative potential for injured renal epithelial cells. Intriguingly, CD24+CD133+ renal progenitors also represent common progenitors of tubular cells and podocytes during renal development. Chronic injury causes dysfunction of the tubular epithelial cells, which triggers the release of fibrogenic cytokines and recruitment of inflammatory cells to injured kidneys. The rapid interposition of scar tissue probably confers a survival advantage by preventing infectious microorganisms from invading the wound, but prevents subsequent tissue regeneration. However, the existence of renal epithelial progenitors in the kidney suggests a possible explanation for the regression of renal lesions which has been observed in experimental animals and even in humans. Thus, manipulation of the wound repair process in order to shift it towards regeneration will probably require the ability to slow the rapid fibrotic response so that renal progenitor cells can allow tissue regeneration rather than scar formation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.