ArticleCancer science2009
Genetic variants of C1orf10 and risk of esophageal squamous cell carcinoma in a Chinese population.
Article in Cancer science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Review
- Endoscopic features of esophageal high-grade intraepithelial neoplasia dominated by cytological atypia.American journal of cancer research · 2022Article
- Downregulation of CRNN gene and genomic instability at 1q21.3 in oral squamous cell carcinoma.Clinical oral investigations · 2015Article
- Epidemiological studies of esophageal cancer in the era of genome-wide association studies.World journal of gastrointestinal pathophysiology · 2014Review
- Caspase8 rs1035142 G>T polymorphism was associated with an increased risk of esophageal cancer in a Chinese population.Molecular biology reports · 2014Article
- Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma.PloS one · 2013Article
- Genetic variant in CASP3 affects promoter activity and risk of esophageal squamous cell carcinoma.Cancer science · 2012Article
- Expression of NDRG2 in esophageal squamous cell carcinoma.Cancer science · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome 1 open reading frame 10 (C1orf10) is either down-regulated or absent in esophageal squamous cell carcinoma (ESCC) tissues compared to its corresponding normal counterparts, and it is involved in heat shock and ethanol response and is expected to protect esophageal epithelium from damage. In the present study, we sequenced DNA samples from 32 individuals to search for genetic variants in the promoter region, coding region, and the untranslated region of C1orf10. Genotypes were analyzed in 991 patients and 984 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. Luciferase assays were carried out to find the functional SNPs. Six strongly linked single nucleotide polymorphisms (SNPs) spanning a region of 7 kb, -1747G/T, -1139G/C, -1079G/A, -900G/T, Gly480Ser, and 4666G/A were identified (D'= 1, r(2 )= 1). Only one SNP -1139G/C was selected to analyze the association between C1orf10 genotypes and risk of ESCC. Subjects with the -1139CC genotype had a greater risk of developing ESCC compared with those with the -1139GG genotype (adjusted OR = 1.34; 95% CI, 1.02-1.76). There appears to be an interaction between the -1139G/C polymorphism and tobacco smoking that contributes to the risk for ESCC. However, we did not detect any obvious difference in reporter gene assay driven by each allele of C1orf10 promoter or 3' UTR. These data showed that C1orf10 haplotypes containing -1747G/T, -1139G/C, -1079G/A, -900G/T, Gly480Ser, and 4666G/A are significantly associated with susceptibility to ESCC.
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