ReviewThe International journal of developmental biology2009
Generation of pattern and form in the developing limb.
Review in The International journal of developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 59 citations in OpenAlex.
- ECM alterations in Fndc3a (Fibronectin Domain Containing Protein 3A) deficient zebrafish cause temporal fin development and regeneration defects.Scientific reports · 2019Article
- Coordinated development of the limb musculoskeletal system: Tendon and muscle patterning and integration with the skeleton.Developmental biology · 2017Review
- Limb proportions show developmental plasticity in response to embryo movement.Scientific reports · 2017Article
- Mechanoadaptation of developing limbs: shaking a leg.Journal of anatomy · 2014Review
- Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cartilage to bone transitions in health and disease.The Journal of endocrinology · 2013Review
- Molecular analysis of regulative events in the developing chick limb.Journal of anatomy · 2013Article
- Experimental approaches for gene regulatory network construction: the chick as a model system.Genesis (New York, N.Y. : 2000) · 2013Review
- Smad1/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death.Developmental biology · 2012Article
- Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra.Current gerontology and geriatrics research · 2012Article
- Phocomelia: a worldwide descriptive epidemiologic study in a large series of cases from the International Clearinghouse for Birth Defects Surveillance and Research, and overview of the literature.American journal of medical genetics. Part C, Seminars in medical genetics · 2011Review
- Initial cell type choice in Dictyostelium.Eukaryotic cell · 2011Review
- Pattern formation today.The International journal of developmental biology · 2009Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The developing limb is a major model for pattern formation in vertebrate embryos. Many of the seminal discoveries of the mechanisms involved in patterning have been made using chick embryos because of the ease of manipulating their developing limbs. More recently, the molecular basis of limb pattern formation has been increasingly uncovered and now, with the availability of genomic resources, the genetic approaches available are even more powerful. Nevertheless, since the limb is ultimately built of cells, gene action must ultimately be translated into cell behaviour and a major challenge will be to integrate genetics with molecular and cellular biology. In this review, we will first outline the stages in limb development, the major interacting signalling pathways that pattern the limb and the molecules involved. We will describe fate maps of the developing limb, and discuss what is known about cellular activities including proliferation, death, adhesiveness, communication and migration during the patterning process. Finally we will explore how these cell activities produce form.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.