ArticleImmunogenetics2009
Polymorphism and selection in the major histocompatibility complex DRA and DQA genes in the family Equidae.
Article in Immunogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Meta-analysis of major histocompatibility complex (MHC) class IIA reveals polymorphism and positive selection in many vertebrate species.Molecular ecology · 2022Pooled it
- Research Progress on the Major Histocompatibility Complex in Herbivores: Structure, Genetics, and Disease Resistance.Biology · 2026Review
- Genetic susceptibility to sarcoid in Arabian horses: associations with MHC class II and compound MHC class I/KLRA genotypes.Veterinary research communications · 2025Article
- Twelve toll-like receptor (TLR) genes in the family Equidae - comparative genomics, selection and evolution.Veterinary research communications · 2024Article
- Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae.BMC genomics · 2020Article
- Inter- and intrabreed diversity of the major histocompatibility complex (MHC) in primitive and draft horse breeds.PloS one · 2020Article
- Genetic variation and selection in the major histocompatibility complex Class II gene in the Guizhou pony.PeerJ · 2020Article
- Copy number variations in Friesian horses and genetic risk factors for insect bite hypersensitivity.BMC genetics · 2018Article
- Inferring the evolution of the major histocompatibility complex of wild pigs and peccaries using hybridisation DNA capture-based sequencing.Immunogenetics · 2018Article
- MHC haplotype diversity in Persian Arabian horses determined using polymorphic microsatellites.Immunogenetics · 2018Article
- Polymorphism at expressed DQ and DR loci in five common equine MHC haplotypes.Immunogenetics · 2017Article
- Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?Journal of immunology research · 2015Review
- Parasite-mediated selection drives an immunogenetic trade-off in plains zebras (Equus quagga).Proceedings. Biological sciences · 2014Article
- Swine Leukocyte Antigen-DQA Gene Variation and Its Association with Piglet Diarrhea in Large White, Landrace and Duroc.Asian-Australasian journal of animal sciences · 2013Article
- Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses.Molecular biology reports · 2013Article
- Article
- Evidence for evolutionary convergence at MHC in two broadly distributed mesocarnivores.Immunogenetics · 2012Article
- The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations.Immunogenetics · 2012Article
- Unraveling the effects of selection and demography on immune gene variation in free-ranging plains zebra (Equus quagga) populations.PloS one · 2012Article
- Adaptive molecular evolution of the Major Histocompatibility Complex genes, DRA and DQA, in the genus Equus.BMC evolutionary biology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major histocompatibility complex genes coding for antigen binding and presenting molecules are the most polymorphic genes in the vertebrate genome. We studied the DRA and DQA gene polymorphism of the family Equidae. In addition to 11 previously reported DRA and 24 DQA alleles, six new DRA sequences and 13 new DQA alleles were identified in the genus Equus. Phylogenetic analysis of both DRA and DQA sequences provided evidence for trans-species polymorphism in the family Equidae. The phylogenetic trees differed from species relationships defined by standard taxonomy of Equidae and from trees based on mitochondrial or neutral gene sequence data. Analysis of selection showed differences between the less variable DRA and more variable DQA genes. DRA alleles were more often shared by more species. The DQA sequences analysed showed strong amongst-species positive selection; the selected amino acid positions mostly corresponded to selected positions in rodent and human DQA genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.