ArticleClinical reviews in allergy & immunology2010
The pathogenesis of neural injury in animal models of the antiphospholipid syndrome.
Article in Clinical reviews in allergy & immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Remote Adolescent-Onset Chorea Preceding Thrombotic Antiphospholipid Syndrome: A Case Report.Cureus · 2026Article
- Cardiolipin Antibody: A Potential Biomarker for Depression.Journal of personalized medicine · 2022Article
- The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases.International journal of molecular sciences · 2021Review
- Non-Criteria Manifestations of Juvenile Antiphospholipid Syndrome.Journal of clinical medicine · 2021Review
- Association between dementia and systemic rheumatic disease: A nationwide population-based study.PloS one · 2021Article
- Antiphospholipid syndrome: a case report with an unusual wide spectrum of clinical manifestations.Auto- immunity highlights · 2019Article
- Article
- Antiphospholipid Syndrome and the Neurologist: From Pathogenesis to Therapy.Frontiers in neurology · 2018Review
- Presence of Anticardiolipin Antibodies in Patients with Dementia: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2017Article
- Non-stroke Central Neurologic Manifestations in Antiphospholipid Syndrome.Current rheumatology reports · 2016Review
- Biomarkers for CNS involvement in pediatric lupus.Biomarkers in medicine · 2015Review
- Immunoglobulin-mediated neuro-cognitive impairment: new data and a comprehensive review.Clinical reviews in allergy & immunology · 2013Review
- Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice.BMC medicine · 2013Article
- The future of autoimmunity.Clinical reviews in allergy & immunology · 2012Article
- Cognitive impairment in antiphospholipid syndrome: evidence from animal models.Clinical rheumatology · 2012Review
- Cognitive dysfunction and antiphospholipid antibodies.Current rheumatology reports · 2012Review
- Antiphospholipid-related chorea.Frontiers in neurology · 2012Article
- Neuromyelitis Optica-AQP4: an update.Current rheumatology reports · 2011Review
- Cutting-edge issues in organ-specific autoimmunity.Clinical reviews in allergy & immunology · 2011Article
- Pathogenesis of antiphospholipid syndrome: understanding the antibodies.Nature reviews. Rheumatology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating antiphospholipid antibodies (aPL) are associated with central nervous system dysfunction in antiphospholipid syndrome (APS) patients and in a mouse model of APS. We propose a logical pathway of how experimental APS (eAPS) causes brain dysfunction: binding of the antibodies to the brain endothelium evoking microthrombosis, endothelial dysfunction, and IgG leakage through the blood-brain barrier (BBB), then secondary inflammatory cell spread around blood vessels and production of cytokines by these inflammatory cells leading to further disruption of the BBB. The diffuse brain endothelial dysfunction would result in extravasation of serum proteins including APS IgG and activated thrombin, which may induce the behavioral changes observed in the APS mice. We have collected data from the mouse eAPS model which supports this hypothesis. Elucidating the mechanism of the pathogenicity of aPL in vitro and in vivo will serve as a much needed basis for developing new therapeutic modalities in this important disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.