SynthesisPLoS genetics2009
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
Erratum issuedOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 274 papers, 21 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 21 pooled it
11.6field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
274 citing papers in PubMed, 21 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies.Communications biology · 2024Pooled it
- Efficacy and safety of subcutaneous semaglutide in adults with overweight or obese: a subgroup meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2023Pooled it
- Associations between Genotype-Diet Interactions and Weight Loss-A Systematic Review.Nutrients · 2020Pooled it
- GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.Science advances · 2019Pooled it
- Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.International journal of obesity (2005) · 2018Pooled it
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Nature communications · 2017Pooled it
- FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.BMJ (Clinical research ed.) · 2016Pooled it
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Nature communications · 2016Pooled it
- Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.Scientific reports · 2016Pooled it
- Pleiotropic genes for metabolic syndrome and inflammation.Molecular genetics and metabolism · 2014Pooled it
- Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals.Diabetologia · 2013Pooled it
- Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.American journal of epidemiology · 2013Pooled it
- A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila.Molecular psychiatry · 2013Pooled it
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Nature genetics · 2012Pooled it
- A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations.European journal of human genetics : EJHG · 2012Pooled it
- Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.Diabetologia · 2012Pooled it
- Implication of European-derived adiposity loci in African Americans.International journal of obesity (2005) · 2012Pooled it
- Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.PLoS genetics · 2012Pooled it
- Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.PLoS genetics · 2012Pooled it
214 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
146 authors at 20 institutions in 11 countries.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, , Oxford, United Kingdom.
Iris M Heid
Joshua C Randall
Claudia Lamina
Valgerdur Steinthorsdottir
Lu Qi
Elizabeth K Speliotes
Gudmar Thorleifsson
Cristen J Willer
Blanca M Herrera
Anne U Jackson
Noha Lim
Paul Scheet
Nicole Soranzo
Najaf Amin
Yurii S Aulchenko
John C Chambers
Alexander Drong
Jian'an Luan
Helen N Lyon
Fernando Rivadeneira
Serena Sanna
Nicholas J Timpson
M Carola Zillikens
Jing Hua Zhao
Peter Almgren
Stefania Bandinelli
Amanda J Bennett
Richard N Bergman
Lori L Bonnycastle
Suzannah J Bumpstead
Stephen J Chanock
Lynn Cherkas
Peter Chines
Lachlan Coin
Cyrus Cooper
Gabriel Crawford
Angela Doering
Anna Dominiczak
Alex S F Doney
Shah Ebrahim
Paul Elliott
Michael R Erdos
Karol Estrada
Luigi Ferrucci
Guido Fischer
Nita G Forouhi
Christian Gieger
Harald Grallert
Christopher J Groves
Scott Grundy
Candace Guiducci
David Hadley
Anders Hamsten
Aki S Havulinna
Albert Hofman
Rolf Holle
John W Holloway
Thomas Illig
Bo Isomaa
Leonie C Jacobs
Karen Jameson
Pekka Jousilahti
Fredrik Karpe
Johanna Kuusisto
Jaana Laitinen
G Mark Lathrop
Debbie A Lawlor
Massimo Mangino
Wendy L McArdle
Thomas Meitinger
Mario A Morken
Andrew P Morris
Patricia Munroe
Narisu Narisu
Anna Nordström
Peter Nordström
Ben A Oostra
Colin N A Palmer
Felicity Payne
John F Peden
Inga Prokopenko
Frida Renström
Aimo Ruokonen
Veikko Salomaa
Manjinder S Sandhu
Laura J Scott
Angelo Scuteri
Kaisa Silander
Kijoung Song
Xin Yuan
Heather M Stringham
Amy J Swift
Tiinamaija Tuomi
Manuela Uda
Peter Vollenweider
Gerard Waeber
Chris Wallace
G Bragi Walters
Michael N Weedon
Wellcome Trust Case Control Consortium
Jacqueline C M Witteman
Cuilin Zhang
Weihua Zhang
Mark J Caulfield
Francis S Collins
George Davey Smith
Ian N M Day
Paul W Franks
Andrew T Hattersley
Frank B Hu
Marjo-Riitta Jarvelin
Augustine Kong
Jaspal S Kooner
Markku Laakso
Edward Lakatta
Vincent Mooser
Andrew D Morris
Leena Peltonen
Nilesh J Samani
Timothy D Spector
David P Strachan
Toshiko Tanaka
Jaakko Tuomilehto
André G Uitterlinden
Cornelia M van Duijn
Nicholas J Wareham
Hugh Watkins
Procardis Consortia
Dawn M Waterworth
Michael Boehnke
Panos Deloukas
Leif Groop
David J Hunter
Unnur Thorsteinsdottir
David Schlessinger
H-Erich Wichmann
Timothy M Frayling
Gonçalo R Abecasis
Joel N Hirschhorn
Ruth J F Loos
Kari Stefansson
Karen L Mohlke
Inês Barroso
Mark I McCarthy
Giant Consortium
Erasmus MC · NLCentre for Human Genetics · GBHelmholtz Zentrum München · DEBroad Institute · USNational Human Genome Research Institute · USUniversity of Michigan · USAddenbrooke's Hospital · GBdeCODE Genetics (Iceland) · ISUniversity of Bristol · GBInstitute for Molecular Medicine Finland · FIImperial College London · GBKing's College London · GBNational Institute on Aging · USUmeå University · SEUniversity of Helsinki · FIPeninsula College of Medicine and Dentistry · GBQueen Mary University of London · GBUniversity of Oxford · GBUniversity of Southampton · GBWellcome Sanger Institute · GB
Funding
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MRESEARCH TRAINING IN DIGESTIVE DISEASES AND NUTRITIONT32DK007191 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1986 to 2026
$14.6MCell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MQUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCER01DK029867 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MARILYN ADER · 1986 to 2026
$11.0MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MGENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2MAging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7MGenetics of cardiovascular risk factors in large founder population birth controlR01HL087679 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HIRSCHHORN, JOEL N · 2007 to 2009
$4.0MComputational and Statistical Models for Human PedigreesR01HG002651 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2003 to 2008
$2.9MGENOTYPING FOR LOCATING HUMAN DISEASE GENESN01HG065403 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID L · 1996 to 2000
$1.7MBiotechnology and Biological Sciences Research CouncilBritish Heart FoundationIntramural NIH HHS Z01 HG000024Medical Research Council 0600705Medical Research Council G0000649Medical Research Council G0000934Medical Research Council G0500539Medical Research Council G0600705Medical Research Council G0600717Medical Research Council G0601261Medical Research Council G0701863Medical Research Council G0801056Medical Research Council G9521010Medical Research Council G9521010DMedical Research Council MC_QA137934Medical Research Council MC_U106188470Medical Research Council MC_UP_A620_1014NHGRI NIH HHS N01 HG065403NHGRI NIH HHS R01 HG002651NHLBI NIH HHS HL084729NHLBI NIH HHS HL087679NHLBI NIH HHS R01 HL087679NHLBI NIH HHS U01 HL084729NIDDK NIH HHS DK062370NIDDK NIH HHS DK067288NIDDK NIH HHS DK07191NIDDK NIH HHS DK072193NIDDK NIH HHS DK075787NIDDK NIH HHS DK079466NIDDK NIH HHS DK080145NIDDK NIH HHS F32 DK079466NIDDK NIH HHS K23 DK067288NIDDK NIH HHS K23 DK080145NIDDK NIH HHS R01 DK029867NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R56 DK062370NIDDK NIH HHS T32 DK007191NIDDK NIH HHS U01 DK062370Wellcome Trust 064890Wellcome Trust 068545/Z/02Wellcome Trust 081682Wellcome Trust 086596/Z/08/ZWellcome Trust 090532Wellcome Trust GR069224Wellcome Trust GR072960Wellcome Trust GR076113
Abstract
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
Indexed as
AdiposityBody Fat DistributionGenome-Wide Association StudyAdultCohort StudiesFemaleHumansLysophospholipaseMaleMethionine Sulfoxide ReductasesObesityOxidoreductasesPolymorphism, Single NucleotideTranscription Factor AP-2Waist CircumferenceWaist-Hip RatioLysophospholipasemethionine sulfoxide reductaseMethionine Sulfoxide ReductasesOxidoreductasesTFAP2B protein, humanTranscription Factor AP-2
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