ArticleCell death and differentiation2009
Cell-autonomous requirement for DNaseII in nonapoptotic cell death.
Article in Cell death and differentiation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Hurdles of Sperm Success: Exploring the Role of DNases.International journal of molecular sciences · 2025Review
- Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification.Frontiers in cell death · 2025Article
- Necrosensor: a genetically encoded fluorescent sensor for visualizing necrosis in Drosophila.Biology open · 2024Article
- Finishing the egg.Genetics · 2024Article
- Review
- An RNAi screen of the kinome in epithelial follicle cells of the Drosophila melanogaster ovary reveals genes required for proper germline death and clearance.G3 (Bethesda, Md.) · 2021Article
- Progesterone depletion results in Lamin B1 loss and induction of cell death in mouse trophoblast giant cells.PloS one · 2021Article
- Cell death in animal development.Development (Cambridge, England) · 2020Review
- Nuclear degradation dynamics in a nonapoptotic programmed cell death.Cell death and differentiation · 2020Article
- Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression.Cell death & disease · 2019Article
- I Spy in the Developing Fly a Multitude of Ways to Die.Journal of developmental biology · 2018Review
- Dnases in health and disease.Developmental biology · 2017Review
- Non-apoptotic cell death in animal development.Cell death and differentiation · 2017Review
- Article
- Phagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovary.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos.Bioscience reports · 2015Article
- Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.Cell reports · 2014Article
- Detecting apoptosis in Drosophila tissues and cells.Methods (San Diego, Calif.) · 2014Review
- DNA degradation and its defects.Cold Spring Harbor perspectives in biology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
DNA fragmentation is a critical component of apoptosis but it has not been characterized in nonapoptotic forms of cell death, such as necrosis and autophagic cell death. In mammalian apoptosis, caspase-activated DNase cleaves DNA into nucleosomal fragments in dying cells, and subsequently DNase II, an acid nuclease, completes the DNA degradation but acts non-cell autonomously within lysosomes of engulfing cells. Here we examine the requirement for DNases during two examples of programmed cell death (PCD) that occurs in the Drosophila melanogaster ovary, starvation-induced death of mid-stage egg chambers and developmental nurse cell death in late oogenesis. Surprisingly, we found that DNaseII was required cell autonomously in nurse cells during developmental PCD, indicating that it acts within dying cells. Dying nurse cells contain autophagosomes, indicating that autophagy may contribute to these forms of PCD. Furthermore, we provide evidence that developmental nurse cell PCD in late oogenesis shows hallmarks of necrosis. These findings indicate that DNaseII can act cell autonomously to degrade DNA during nonapoptotic cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.