ArticleCell cycle (Georgetown, Tex.)2009
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.
Article in Cell cycle (Georgetown, Tex.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Detection of chromosomal alteration after infusion of gene-edited allogeneic CAR T cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Somatic inactivation of ATM in hematopoietic cells predisposes mice to cyclin D3 dependent T cell acute lymphoblastic leukemia.Cell cycle (Georgetown, Tex.) · 2015Article
- Rapid analysis of chromosome aberrations in mouse B lymphocytes by PNA-FISH.Journal of visualized experiments : JoVE · 2014Article
- Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia.Cell cycle (Georgetown, Tex.) · 2014Article
- A new take on v(d)j recombination: transcription driven nuclear and chromatin reorganization in rag-mediated cleavage.Frontiers in immunology · 2013Review
- Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.Nucleic acids research · 2013Article
- The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.Nature communications · 2013Article
- Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.The Journal of cell biology · 2012Article
- How does DNA break during chromosomal translocations?Nucleic acids research · 2011Review
- Article
- ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks.PLoS genetics · 2010Article
- ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.The Journal of experimental medicine · 2010Article
- Review
- AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.Molecular cell · 2009Article
- It takes two: communication between homologous alleles preserves genomic stability during V(D)J recombination.Nucleus (Austin, Tex.)Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Translocations involving the T cell receptor alpha/delta (TCRalpha/delta) chain locus, which bring oncogenes in the proximity of the TCRalpha enhancer, are one of the hallmark features of human T cell malignancies from ataxia telangiectasia (AT) and non-AT patients. These lesions are frequently generated by the fusion of DNA breaks at the TCRalpha/delta locus to a disperse region centromeric of the immunoglobulin heavy chain (IgH) locus. Aberrant VDJ joining accounts for TCRalpha/delta associated DNA cleavage, but the molecular mechanism that leads to generation of the "oncogene partner" DNA break is unclear. Here we show that in ATM deficient primary mouse T cells, IgH/TCRalpha/delta fusions arise at a remarkably similar frequency as in human AT lymphocytes. Recombinase-activating gene (RAG) is responsible for both TCRalpha/delta as well as IgH associated breaks on chromosome 12 (Chr12), which are subject to varying degrees of chromosomal degradation. We suggest a new model for how oncogenic translocations can arise from two non-concerted physiological DSBs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.