ReviewStereotactic and functional neurosurgery2009
The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia.
Review in Stereotactic and functional neurosurgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies.Biology of sex differences · 2024Pooled it
- A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Transsynaptic neural circuit mapping of ventral hippocampus motivational control systems.Brain structure & function · 2026Article
- A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region.Briefings in bioinformatics · 2026Article
- Review
- A ventral hippocampus to nucleus accumbens pathway regulates impulsivity.bioRxiv : the preprint server for biology · 2025Article
- White matter abnormalities of the frontal-striatal-thalamic circuit in individuals with attenuated positive symptom syndromes: a probabilistic tractography study.Schizophrenia (Heidelberg, Germany) · 2025Article
- Deep brain stimulation of Hippocampus in Treatment-resistant Schizophrenia (DBS-HITS): protocol for a crossover randomized controlled trial.BMC psychiatry · 2024Article
- Structural correlations between brain magnetic resonance image-derived phenotypes and retinal neuroanatomy.European journal of neurology · 2024Article
- The altered volume of striatum: A neuroimaging marker of treatment in first-episode and drug-naïve schizophrenia.Schizophrenia research. Cognition · 2024Article
- Enlarged basal ganglia in drug-naïve patients with first-episode psychosis immediately upon symptom onset.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2024Article
- Dopamine Synthesis Capacity and GABA and Glutamate Levels Separate Antipsychotic-Naïve Patients With First-Episode Psychosis From Healthy Control Subjects in a Multimodal Prediction Model.Biological psychiatry global open science · 2023Article
- Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment.Molecular psychiatry · 2022Review
- The alternations of nucleus accumbent in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment.Frontiers in psychiatry · 2022Article
- A computational lens on menopause-associated psychosis.Frontiers in psychiatry · 2022Article
- Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function.Translational psychiatry · 2021Article
- Successful Treatment of Psychiatric Symptoms after Traumatic Brain Injury Using Deep Brain Stimulation to the Anterior Limb of Internal Capsule-Nucleus Accumbens.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Some animal models are more equal than others: Cortico-striatal circuits for translation.Lab animal · 2020Article
- Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder.Scientific reports · 2019Article
- Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats.Scientific reports · 2019Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
Schizophrenia is a chronic and disabling psychiatric illness that is often refractory to treatment. Psychotic symptoms (e.g. hallucinations and delusions) in schizophrenia are reliably correlated with excess dopamine levels in the striatum, and have more recently been related to excess metabolic activity in the hippocampus. Multiple lines of evidence suggest that aberrantly high hippocampal activity may, via hippocampal connections with the limbic basal ganglia, drive excessive dopamine release into the striatum. In the present paper, we hypothesize that inhibition or stabilization of neural activity with high-frequency electrical stimulation of the hippocampus or nucleus accumbens, through different mechanisms, would treat the positive symptoms of schizophrenia. Thus, we suggest a direction for further experimentation aimed at developing neurosurgical therapeutic approaches for this devastating disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.