ArticleCytogenetic and genome research2009
Interaction study of the male specific lethal (MSL) complex and trans-acting dosage effects in metafemales of Drosophila melanogaster.
Article in Cytogenetic and genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Genome-Wide Expression Analysis of Long Noncoding RNAs and Their Target Genes in MetafemaleInternational journal of molecular sciences · 2023Article
- Dosage Compensation inInternational journal of molecular sciences · 2022Review
- Interaction of Male Specific Lethal complex and genomic imbalance on global gene expression in Drosophila.Scientific reports · 2021Article
- Correct dosage of X chromosome transcription is controlled by a nuclear pore component.Cell reports · 2021Article
- Dosage Compensation in Drosophila-a Model for the Coordinate Regulation of Transcription.Genetics · 2016Review
- Facts and artifacts in studies of gene expression in aneuploids and sex chromosomes.Chromosoma · 2014Review
- Differential effect of aneuploidy on the X chromosome and genes with sex-biased expression in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Dosage compensation and inverse effects in triple X metafemales of Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Male-specific lethal complex in Drosophila counteracts histone acetylation and does not mediate dosage compensation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Identification of Inverse Regulator-a (Inr-a) as Synonymous with Pre-mRNA Cleavage Complex II Protein (Pcf11) in Drosophila.G3 (Bethesda, Md.) · 2012Article
- Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription.Nature reviews. Genetics · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The effect of ectopic expression of male specific lethal 2 (msl2) on chromatin modification and gene expression was studied in Drosophila diploid females and metafemales (3X;2A). Results show that ectopic expression of MSL2 in transgenic msl2 females and metafemales sequesters the MOF histone acetylase to the X, which occurs concordantly with an increase of histone acetylation. Gene expression studies indicate that the X-linked genes are not affected by direct targeting of the MSL complex and the resulting increased H4Lys16 acetylation on the X chromosomes, suggesting one function of the MSL complex is to nullify the effect of a high level of histone acetylation. These results are not consistent with the hypothesis that the presence of the MSL complex conditions a two-fold upregulation. Autosomal gene expression is generally decreased in ectopically expressed MSL2 females, which correlates with the reduced autosomal histone acetylation. Metafemales show dosage compensation of X-linked genes with some autosomal reductions in expression. Interestingly, in metafemales with ectopically expressed MSL2, the autosomal expression is returned to a more normal level. There is a lower autosomal level of histone acetylation compared to the normal metafemales, suggesting a nullifying effect on the negative dosage effect of the X chromosome as previously hypothesized to occur in normal males.
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Registered trials
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