ArticleJournal of lipid research2010
ABCD2 is abundant in adipose tissue and opposes the accumulation of dietary erucic acid (C22:1) in fat.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Regulation of base excision repair during adipogenesis and osteogenesis of bone marrow-derived mesenchymal stem cells.Scientific reports · 2023Article
- Spatiotemporal Regulation and Functional Analysis of Circular RNAs in Skeletal Muscle and Subcutaneous Fat during Pig Growth.Biology · 2021Article
- Peroxisomal ABC Transporters: An Update.International journal of molecular sciences · 2021Review
- High-dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy.Brain pathology (Zurich, Switzerland) · 2020Article
- Peroxisomal ATP-binding cassette transporters form mainly tetramers.The Journal of biological chemistry · 2017Article
- Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.Cell death and differentiation · 2015Article
- Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.Acta neuropathologica · 2015Article
- ABCD2 identifies a subclass of peroxisomes in mouse adipose tissue.Biochemical and biophysical research communications · 2015Article
- ABCD2 alters peroxisome proliferator-activated receptor α signaling in vitro, but does not impair responses to fenofibrate therapy in a mouse model of diet-induced obesity.Molecular pharmacology · 2014Article
- Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.The Journal of biological chemistry · 2014Article
- Caveolar fatty acids and acylation of caveolin-1.PloS one · 2013Article
- The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation.The Journal of biological chemistry · 2012Article
- The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid.Journal of lipid research · 2012Article
- Differential fatty acid profile in adipose and non-adipose tissues in obese mice.International journal of clinical and experimental medicine · 2010Article
- General aspects and neuropathology of X-linked adrenoleukodystrophy.Brain pathology (Zurich, Switzerland) · 2010Review
- Pathomechanisms underlying X-adrenoleukodystrophy: a three-hit hypothesis.Brain pathology (Zurich, Switzerland) · 2010Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The ATP binding cassette transporter, ABCD2 (D2), is a peroxisomal protein whose mRNA has been detected in the adrenal, brain, liver, and fat. Although the role of this transporter in neural tissues has been studied, its function in adipose tissue remains unexplored. The level of immunoreactive D2 in epididymal fat is >50-fold of that found in brain or adrenal. D2 is highly enriched in adipocytes and is upregulated during adipogenesis but is not essential for adipocyte differentiation or lipid accumulation in day 13.5 mouse embryonic fibroblasts isolated from D2-deficient (D2(-/-)) mice. Although no differences were appreciated in differentiation percentage, total lipid accumulation was greater in D2(-/-) adipocytes compared with the wild type. These results were consistent with in vivo observations in which no significant differences in adiposity or adipocyte diameter between wild-type and D2(-/-) mice were observed. D2(-/-) adipose tissue showed an increase in the abundance of 20:1 and 22:1 fatty acids. When mice were challenged with a diet enriched in erucic acid (22:1), this lipid accumulated in the adipose tissue in a gene-dosage-dependent manner. In conclusion, D2 is a sterol regulatory element binding protein target gene that is highly abundant in fat and opposes the accumulation of dietary lipids generally absent from the triglyceride storage pool within adipose tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.