ArticleProceedings of the National Academy of Sciences of the United States of America2009
High cGMP synthetic activity in carp cones.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Restoring Sight: The Journey of AIPL1 from Discovery to Therapy.International journal of molecular sciences · 2025Review
- Colonic phosphocholine is correlated with Candida tropicalis and promotes diarrhea and pathogen clearance.NPJ biofilms and microbiomes · 2023Article
- Mathematical analysis of phototransduction reaction parameters in rods and cones.Scientific reports · 2022Article
- A kinetic analysis of mouse rod and cone photoreceptor responses.The Journal of physiology · 2020Article
- Elevated energy requirement of cone photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Multi-scale, numerical modeling of spatio-temporal signaling in cone phototransduction.PloS one · 2019Article
- Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors.Progress in retinal and eye research · 2018Review
- Investigating the CaScientific reports · 2018Article
- The NaeLife · 2017Article
- The retina visual cycle is driven by cis retinol oxidation in the outer segments of cones.Visual neuroscience · 2017Article
- Purification of cone outer segment for proteomic analysis on its membrane proteins in carp retina.PloS one · 2017Article
- Why are rods more sensitive than cones?The Journal of physiology · 2016Review
- Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Activation and quenching of the phototransduction cascade in retinal cones as inferred from electrophysiology and mathematical modeling.Molecular vision · 2015Article
- Article
- Difference in the gain in the phototransduction cascade between rods and cones in carp.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Identification of target binding site in photoreceptor guanylyl cyclase-activating protein 1 (GCAP1).The Journal of biological chemistry · 2014Article
- Membrane guanylyl cyclase complexes shape the photoresponses of retinal rods and cones.Frontiers in molecular neuroscience · 2014Review
- Circadian phase-dependent effect of nitric oxide on L-type voltage-gated calcium channels in avian cone photoreceptors.Journal of neurochemistry · 2013Article
- Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cones show briefer light responses than rods and do not saturate even under very bright light. Using purified rod and cone homogenates, we measured the activity of guanylate cyclase (GC), an enzyme responsible for cGMP synthesis and therefore recovery of a light response. The basal GC activity was 36 times higher in cones than in rods: It was mainly caused by higher expression levels of GC in cones (GC-C) than in rods (GC-R). With identification and quantification of GC-activating protein (GCAP) subtypes expressed in rods and cones together with determination of kinetic parameters of GC activation in the presence and absence of GCAP, we estimated the in situ GC activity in rods and cones at low and high Ca(2+) concentrations. It was revealed that the GC activity would be >10 times higher in cones than in rods in both the dark-adapted and the light-adapted states. Electrophysiological estimation of the GC activity measured in the truncated preparations of rod and cone outer segments gave consistent results. Our estimation of the in situ GC activity reasonably explained the rapid recovery and nonsaturating behavior of cone light responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.